The effect of novel vitamin D3 compounds on saliva samples from COVID-19 patients: a lab study.

Autor: Feteih SMN; Department of Dentistry, Periodontology, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia. sfeteih@kfshrc.edu.sa., Dada A; Department of Pathology & Laboratory Medicine, Head, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia., Heaphy ELG; Department of Research Center, Epidemiology, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia., Zailaie S; Department of Research Center, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia., Jan D; Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Virology Technology, Jeddah, Saudi Arabia., Rashed Z; Pharmacy Department, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia., Wali G; Department of Medicine, Infectious Diseases, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Aug 21; Vol. 14 (1), pp. 19415. Date of Electronic Publication: 2024 Aug 21.
DOI: 10.1038/s41598-024-70429-z
Abstrakt: Vitamin D has shown antimicrobial effects. This study aimed to explore the antiviral effects of vitamin D3 on saliva samples collected from patients with coronavirus disease-19 (COVID-19) and compare saliva and swab results to aid in policy development. Saliva and swab samples were collected from adult patients with a positive test for COVID-19 at the King Faisal Specialist Hospital and Research Centre, Jeddah. Patients who were immunocompromised and pregnant and aged < 18 years were excluded. Vitamin D3 compound (100, 300, 800, and 1,200 IU) was added to the first saliva sample in the laboratory (n = 20); the rest of the swab specimens were compared with the saliva samples via real-time polymerase chain reaction. Of the 257 patients, 236 (94.8%) had positive saliva sample test results, 7 (2.8%) had errors, and 6 (2.4%) had negative results. Of the 236 positive tests, 235 (99.6%) had a cycle threshold (Ct) indicating strong positive reactions, and only one (Ct = 28.86) was weak. Among the 236 positive results, 235 (99.6%) exhibited robust positive reactions, indicating a substantial positive sample size. Thus, saliva might be a dependable alternative testing tool when obtaining swab samples from patients is inconvenient or challenging.
(© 2024. The Author(s).)
Databáze: MEDLINE
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