Characterization of faecal microbiota and serum inflammatory markers in dogs diagnosed with chronic enteropathy or small-cell lymphoma: a pilot study.

Autor: Kaga C; Yakult Central Institute, Kunitachi-shi, Tokyo, Japan. chiaki-kaga@yakult.co.jp., Kakiyama S; Yakult Central Institute, Kunitachi-shi, Tokyo, Japan., Hokkyo A; Yakult Central Institute, Kunitachi-shi, Tokyo, Japan., Ogata Y; Yakult Central Institute, Kunitachi-shi, Tokyo, Japan., Shibata J; Yakult Central Institute, Kunitachi-shi, Tokyo, Japan., Nagahara T; Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Nakazawa M; Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Nakagawa T; Veterinary Medical Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Tsujimoto H; Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Chambers JK; Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Uchida K; Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Matsumoto S; Yakult Central Institute, Kunitachi-shi, Tokyo, Japan., Kobayashi T; Yakult Central Institute, Kunitachi-shi, Tokyo, Japan., Tomiyasu H; Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Mizusawa N; Yakult Central Institute, Kunitachi-shi, Tokyo, Japan.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Aug 20; Vol. 14 (1), pp. 19387. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1038/s41598-024-69923-1
Abstrakt: Dogs diagnosed with chronic enteropathy (CE) or small-cell lymphoma (SCL) exhibit marked differences in faecal microbiota and organic acid profiles compared with healthy dogs, as well as immune abnormalities in intestinal mucosal tissue. However, few studies have analysed trace organic acids, such as succinic acid, which have been suggested to be associated with IBD in humans. Therefore, in this study, we compared the faecal microbiota and organic acid profiles as well as serum inflammatory markers between dogs with disease (n = 11; 6 with CE and 5 with SCL) and healthy controls (n = 16). We also performed machine learning and correlation analysis to obtain more detailed insights into the characteristics of affected dogs. These results revealed that dogs with CE and SCL had lower levels of Erysipelotrichaceae (e.g. Turicibacter and Allobaculum), exhibited abnormalities in the succinic acid metabolism (i.e. succinic acid accumulation and decreased levels of Phascolarctobacterium as succinic acid-utilising bacteria) and increased levels of pathobiont bacteria such as Escherichia-Shigella. Additionally, the presence of Dubosiella was significantly negatively correlated with Canine Inflammatory Bowel Disease Activity Index scores. These findings are expected to aid the development of microbiome-based medications and/or supplements, although further verification is needed.
(© 2024. The Author(s).)
Databáze: MEDLINE
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