CuSO 4 / N -(9 H -carbazol-9-yl)picolinamide-Catalyzed C-O Coupling of (Hetero)Aryl Chlorides with Phenols on Water.

Autor:	Hong P; School of Chemical Engineering and Technology, Sun Yat-sen University, Zhuhai 519082, P. R. China.; Guangdong Engineering Technology Research Center for Platform Chemicals from Marine Biomass and Their Functionalization, Sun Yat-sen University, Zhuhai 519082, P. R. China., Zhu X; Guangdong Engineering Technology Research Center for Platform Chemicals from Marine Biomass and Their Functionalization, Sun Yat-sen University, Zhuhai 519082, P. R. China.; Instrument Analysis & Research Center, Sun Yat-sen University, Guangzhou 510275, P. R. China., Chen F; School of Chemical Engineering and Technology, Sun Yat-sen University, Zhuhai 519082, P. R. China., Huang M; School of Chemical Engineering and Technology, Sun Yat-sen University, Zhuhai 519082, P. R. China.; Guangdong Engineering Technology Research Center for Platform Chemicals from Marine Biomass and Their Functionalization, Sun Yat-sen University, Zhuhai 519082, P. R. China., Wan Y; School of Chemical Engineering and Technology, Sun Yat-sen University, Zhuhai 519082, P. R. China.; Guangdong Engineering Technology Research Center for Platform Chemicals from Marine Biomass and Their Functionalization, Sun Yat-sen University, Zhuhai 519082, P. R. China.
Jazyk:	angličtina
Zdroj:	Organic letters [Org Lett] 2024 Aug 30; Vol. 26 (34), pp. 7202-7206. Date of Electronic Publication: 2024 Aug 21.
DOI:	10.1021/acs.orglett.4c02620
Abstrakt:	A Cu-catalyzed C-O coupling of (hetero)aryl chlorides with phenols at 120 °C on water was developed with a designed ligand, N -(9 H -carbazol-9-yl)picolinamide ( L2 ). This method features a good substrate scope (both electron-donating and electron-withdrawing), low catalyst/ligand loadings (down to 1 mol %), and excellent scalability and practicability.
Databáze:	MEDLINE
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