Presentation and Outcomes of Lassa Fever in Children in Nigeria: A Prospective Cohort Study (LASCOPE).

Autor:	Duvignaud A; Global Health in the Global South Research Team-University of Bordeaux, National Institute for Health and Medical Research (INSERM) UMR 1219, French Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Research Centre, Bordeaux, France.; Department of Infectious Diseases and Tropical Medicine, Division of Tropical Medicine and Clinical International Health, CHU Bordeaux, Hôpital Pellegrin, Place Amélie Raba Léon, Bordeaux, France.; Programme PAC-CI/ANRS Research Site, University Hospital Centre of Treichville, Abidjan, Côte d'Ivoire.; The Alliance for International Medical Action, Dakar, Senegal., Etafo IC; Lassa Fever Response Team, Infection Control and Research Centre, Federal Medical Centre Owo, Owo, Nigeria., Jaspard M; Global Health in the Global South Research Team-University of Bordeaux, National Institute for Health and Medical Research (INSERM) UMR 1219, French Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Research Centre, Bordeaux, France.; Programme PAC-CI/ANRS Research Site, University Hospital Centre of Treichville, Abidjan, Côte d'Ivoire.; The Alliance for International Medical Action, Dakar, Senegal.; Department of Infectious Diseases and Tropical Medicine, Hôpital Saint Antoine, Assistance Publique Hôpitaux de Paris, Paris, France., Salau Q; Department of Pediatrics, Federal Medical Centre Owo, Owo, Nigeria., Serra B; Global Health in the Global South Research Team-University of Bordeaux, National Institute for Health and Medical Research (INSERM) UMR 1219, French Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Research Centre, Bordeaux, France.; Programme PAC-CI/ANRS Research Site, University Hospital Centre of Treichville, Abidjan, Côte d'Ivoire.; The Alliance for International Medical Action, Dakar, Senegal., Kareem AJ; Department of Pediatrics, Federal Medical Centre Owo, Owo, Nigeria., Juchet S; Global Health in the Global South Research Team-University of Bordeaux, National Institute for Health and Medical Research (INSERM) UMR 1219, French Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Research Centre, Bordeaux, France.; Programme PAC-CI/ANRS Research Site, University Hospital Centre of Treichville, Abidjan, Côte d'Ivoire.; The Alliance for International Medical Action, Dakar, Senegal., Jegede TO; Department of Pediatrics, Federal Medical Centre Owo, Owo, Nigeria., Gabillard D; Global Health in the Global South Research Team-University of Bordeaux, National Institute for Health and Medical Research (INSERM) UMR 1219, French Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Research Centre, Bordeaux, France.; Programme PAC-CI/ANRS Research Site, University Hospital Centre of Treichville, Abidjan, Côte d'Ivoire., Abidoye AT; Lassa Fever Response Team, Infection Control and Research Centre, Federal Medical Centre Owo, Owo, Nigeria., Le Gal C; The Alliance for International Medical Action, Dakar, Senegal., Abejegah C; Lassa Fever Response Team, Infection Control and Research Centre, Federal Medical Centre Owo, Owo, Nigeria., Owhin S; Lassa Fever Response Team, Infection Control and Research Centre, Federal Medical Centre Owo, Owo, Nigeria., Okwaraeke K; The Alliance for International Medical Action, Dakar, Senegal., Doutchi M; The Alliance for International Medical Action, Dakar, Senegal.; Department of Infectious Diseases, Centre Hospitalier National de Zinder, Zinder, Niger., Katembo Vihundira J; The Alliance for International Medical Action, Dakar, Senegal., Besong-Lache RM; The Alliance for International Medical Action, Dakar, Senegal., Seri B; Programme PAC-CI/ANRS Research Site, University Hospital Centre of Treichville, Abidjan, Côte d'Ivoire., Bérerd-Camara M; The Alliance for International Medical Action, Dakar, Senegal., Salam APA; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Olayinka A; Nigeria Centre for Disease Control, Abuja, Nigeria., Horby P; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Ogbaini-Emovon E; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Duraffour S; Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Ahmed LA; Department of Family Medicine, Federal Medical Centre Owo, Owo, Nigeria., Günther S; Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Adedosu AN; Viral Hemorrhagic Fever Laboratory, Infection Control and Research Centre, Federal Medical Centre Owo, Owo, Nigeria., Anglaret X; Global Health in the Global South Research Team-University of Bordeaux, National Institute for Health and Medical Research (INSERM) UMR 1219, French Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Research Centre, Bordeaux, France.; Programme PAC-CI/ANRS Research Site, University Hospital Centre of Treichville, Abidjan, Côte d'Ivoire.; The Alliance for International Medical Action, Dakar, Senegal., Malvy D; Global Health in the Global South Research Team-University of Bordeaux, National Institute for Health and Medical Research (INSERM) UMR 1219, French Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Research Centre, Bordeaux, France.; Department of Infectious Diseases and Tropical Medicine, Division of Tropical Medicine and Clinical International Health, CHU Bordeaux, Hôpital Pellegrin, Place Amélie Raba Léon, Bordeaux, France.; Programme PAC-CI/ANRS Research Site, University Hospital Centre of Treichville, Abidjan, Côte d'Ivoire.; The Alliance for International Medical Action, Dakar, Senegal., Lang HJ; The Alliance for International Medical Action, Dakar, Senegal.; Witten/Herdecke-University, Global Child Health, Witten, Germany., Ayodeji OO; Lassa Fever Response Team, Infection Control and Research Centre, Federal Medical Centre Owo, Owo, Nigeria.
Jazyk:	angličtina
Zdroj:	Journal of the Pediatric Infectious Diseases Society [J Pediatric Infect Dis Soc] 2024 Nov 04; Vol. 13 (10), pp. 513-522.
DOI:	10.1093/jpids/piae083
Abstrakt:	Background: Data on the presentation, management, and outcomes of Lassa fever (LF) in children are limited. Methods: Description of the clinical and biological features, treatment, and outcomes of reverse transcriptase and polymerase chain reaction (RT-PCR)-confirmed LF in children aged under 15, enrolled in the LASsa fever clinical COurse and Prognostic factors in an Epidemic context (LASCOPE) prospective cohort study in Nigeria between April 2018 and February 2023. Results: One hundred twenty-four children (aged under 12 months: 19; over 12 months: 105) were hospitalized with RT-PCR-confirmed LF. All received intravenous ribavirin. During follow-up, 99/124 (80%) had fever; 71/124 (57%) had digestive symptoms, vomiting (n = 56/122, 46%) and abdominal pain (n = 34/78 aged ≥5 years, 44%) more often than diarrhea (n = 19/124, 15%); 17/124 (14%) had hemorrhagic signs; 44/112 (39%) had a hematocrit lower than 25%, of whom 32/44 (73%) received transfusions; 44/88 (50%) developed hypotension; 18/112 (16.1%) developed kidney disease improving global outcome (KDIGO) ≥2 acute kidney injury; 10/112 (8.9%) had KDIGO 3 acute kidney failure; 4/124 (3.2%) underwent renal replacement therapy. Seven children died, including 4 aged under 12 months (case fatality rate: under 12 months-22%, 95% confidence interval (CI): 7%-48%; over 12 months-2.9%, 95% CI: 0.7%-8.7%). In univariable analysis, age (P = .003), impaired consciousness (P = .026), and Lassa RT-PCR Ct value (P = .006) were associated with Day 30 mortality. Conclusions: The fatality rate for children over 12 months hospitalized with LF was lower than that previously reported for adults. Hypotension and acute kidney injury were the most frequent organ dysfunctions. Bleeding was relatively infrequent. Anemia and the need for transfusion were common, the relative contribution of ribavirin-induced hemolysis being unknown. (© The Author(s) 2024. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society.)
Databáze:	MEDLINE
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