Indocyanine Green and Hepatobiliary Surgery: An Overview of the Current Literature.

Autor:	Fortuna L; Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy., Buccianti S; Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy., Risaliti M; Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy., Matarazzo F; Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy., Agostini C; Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy., Ringressi MN; Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy., Taddei A; Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy., Bartolini I; Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy., Grazi GL; Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy.
Jazyk:	angličtina
Zdroj:	Journal of laparoendoscopic & advanced surgical techniques. Part A [J Laparoendosc Adv Surg Tech A] 2024 Oct; Vol. 34 (10), pp. 921-931. Date of Electronic Publication: 2024 Aug 21.
DOI:	10.1089/lap.2024.0166
Abstrakt:	Indocyanine green (ICG) is an inert polypeptide that almost totally binds to high molecular weight plasma proteins; it is cleared by the hepatocytes and directly excreted into the bile with a half-life of about 3-5 minutes. Specific systems are required to see fluorescent images. The use of this dye has been reported in different surgical specialties, and the applications in hepatobiliary surgery are widening. Being firstly used to evaluate the preoperative liver function, intra- and postoperative dynamic checking of hepatic activity has been reported and integrated within perioperative protocols allowing a tailored treatment allocation. Intravenous injection (IV) or injection into the gallbladder can ease difficult cholecystectomy. Biliary leakage detection could be enhanced by IV ICG injection. Although with some contrasting results, the use of ICG for both delineating the limits of the resection and tumor-enhanced visualization was demonstrated to improve short- and long-term outcomes. Although the lack of strong evidence still precludes the introduction of this tool in clinical practice, it harbors great potential in liver surgery.
Databáze:	MEDLINE
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