Use of frozen native feces for fecal microbiota transplantation in recurrent Clostridioides difficile infection: a simple way to improve the efficiency of donor feces preparation.

Autor:	Sintes R; Department of Pharmacy, Sorbonne Université, AP-HP, Saint-Antoine Hospital, Paris, France.; Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France.; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.; French Group for Fecal Microbiota Transplantation (GFTF), Paris, France., McLellan P; Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France.; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.; French Group for Fecal Microbiota Transplantation (GFTF), Paris, France.; Department of Gastroenterology, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint-Antoine Hospital, Paris, France., Navelli G; Department of Pharmacy, Sorbonne Université, AP-HP, Saint-Antoine Hospital, Paris, France.; Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France.; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.; French Group for Fecal Microbiota Transplantation (GFTF), Paris, France., Landman C; Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France.; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.; French Group for Fecal Microbiota Transplantation (GFTF), Paris, France.; Department of Gastroenterology, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint-Antoine Hospital, Paris, France., Delage S; Department of Pharmacy, Sorbonne Université, AP-HP, Saint-Antoine Hospital, Paris, France.; Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France.; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.; French Group for Fecal Microbiota Transplantation (GFTF), Paris, France., Truong S; Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France.; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.; French Group for Fecal Microbiota Transplantation (GFTF), Paris, France.; Department of Gastroenterology, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint-Antoine Hospital, Paris, France., Benech N; French Group for Fecal Microbiota Transplantation (GFTF), Paris, France.; Department of Hepato-Gastroenterology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France., Kapel N; Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France.; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.; French Group for Fecal Microbiota Transplantation (GFTF), Paris, France.; Functional Coprology Laboratory, APHP, Pitié Salpêtrière Hospital and Université Paris Cité, INSERM UMRS-1139, Centre d'Immunologie et des Maladies Infectieuses, (CIMI-PARIS), Inserm U1135, Sorbonne Université, Paris, France., Moreino Sabater A; Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France.; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.; French Group for Fecal Microbiota Transplantation (GFTF), Paris, France.; Sorbonne Université, APHP, National Institute of Health and Medical Research, Center for Immunology and Infectious Diseases-Paris, Saint Antoine Hospital, Parasitology-Mycology, Paris, France., Schnuriger A; Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France.; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.; French Group for Fecal Microbiota Transplantation (GFTF), Paris, France.; Sorbonne Université, AP-HP, Saint-Antoine Hospital, Virology, Paris, France., Eckert C; Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France.; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.; French Group for Fecal Microbiota Transplantation (GFTF), Paris, France.; Sorbonne Université, AP-HP, Saint-Antoine Hospital, Bacteriology et Centre d'Immunologie et des Maladies Infectieuses, INSERM, U1135, Sorbonne Université, Paris, France., Bleibtreu A; Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France.; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.; French Group for Fecal Microbiota Transplantation (GFTF), Paris, France.; Department of Infectious Disease, Sorbonne Université, AP-HP, Pitié-Salpêtrière Hospital, Paris, France., Joly A-C; Department of Pharmacy, Sorbonne Université, AP-HP, Saint-Antoine Hospital, Paris, France.; Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France.; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.; French Group for Fecal Microbiota Transplantation (GFTF), Paris, France., Sokol H; Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France.; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.; French Group for Fecal Microbiota Transplantation (GFTF), Paris, France.; Department of Gastroenterology, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint-Antoine Hospital, Paris, France.; Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France.
Jazyk:	angličtina
Zdroj:	Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Oct 08; Vol. 68 (10), pp. e0073424. Date of Electronic Publication: 2024 Aug 21.
DOI:	10.1128/aac.00734-24
Abstrakt:	Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent Clostridioides difficile infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% ( P = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI. Competing Interests: H.S. reports lecture fee, board membership, or consultancy from Amgen, Fresenius, IPSEN, Actial, Astellas, Danone, THAC, Biose, BiomX, Eligo, Immusmol, Adare, Nestle, Ferring, MSD, Bledina, Pfizer, Biocodex, BMS, Bromatech, Gilead, Janssen, Mayoli, Roche, Sanofi, Servier, Takeda, Abbvie, and Lilly, has stocks from Enterome bioscience, and is co-founder of Exeliom Biosciences.
Databáze:	MEDLINE
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