Respiratory syncytial virus infection in children during SARS-CoV-2 pandemic at a referral center in Rio de Janeiro, Brazil.

Autor:	Lebreiro GP; Departamento de Doenças Infecciosas e Parasitárias, Universidade Federal do Rio de Janeiro - UFRJ - Rio de Janeiro (RJ) Brasil., Venceslau MT; Departamento de Doenças Infecciosas e Parasitárias, Universidade Federal do Rio de Janeiro - UFRJ - Rio de Janeiro (RJ) Brasil., Guimarães MAAM; Departamento de Doenças Infecciosas e Parasitárias, Universidade Federal do Rio de Janeiro - UFRJ - Rio de Janeiro (RJ) Brasil., Abreu TF; Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro - UFRJ - Rio de Janeiro (RJ) Brasil., Rangel Y; Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro - UFRJ - Rio de Janeiro (RJ) Brasil., Frota ACC; Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro - UFRJ - Rio de Janeiro (RJ) Brasil., Hofer CB; Departamento de Doenças Infecciosas e Parasitárias, Universidade Federal do Rio de Janeiro - UFRJ - Rio de Janeiro (RJ) Brasil.
Jazyk:	angličtina
Zdroj:	Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia [J Bras Pneumol] 2024 Aug 19; Vol. 50 (3), pp. e20240072. Date of Electronic Publication: 2024 Aug 19 (Print Publication: 2024).
DOI:	10.36416/1806-3756/e20240072
Abstrakt:	Objective: In order to study the scenario of respiratory infections in pediatrics after the emergence of SARS-CoV-2 in Brazil, this study aimed to compare characteristics of children admitted for SARS or upper airway infection caused by either RSV or SARS-CoV-2. Methods: This was a cross-sectional study involving children up to 48 months of age admitted to a tertiary pediatric hospital with a diagnosis of SARS or upper airway infection between April of 2020 and April of 2021. Respiratory secretion samples were collected 2-5 days after hospitalization, and antigen/PCR tests for viral etiologies were performed. In this analysis, patients with laboratorial diagnosis of SARS-CoV-2 and/or RSV were selected, and their clinical and epidemiological characteristics were compared using logistic regression. Results: Our sample initially comprised 369 participants. SARS-CoV-2 and RSV infections were confirmed in 55 (15%) and 59 children (16%), respectively. Mean age was 12 months (0-48 months), and 47 were female. The following characteristics were significantly more frequent in patients with RSV when compared with those with COVID-19: younger age (OR = 0.94; 95% CI: 0.90-0.98); lower frequency of fever (OR = 0.18; 95% CI: 0.05-0.66); and more frequent upper airway symptoms: cough (OR = 7.36; 95% CI: 1.04-52.25); and tachypnea (OR = 6.06; 95% CI: 1.31-28.0). Conclusions: Children with RSV-related SARS were younger, had lower frequency of fever at admission, but had a higher frequency of signs of upper airway infection and lower systemic inflammation when compared with children hospitalized for COVID-19 during the first year of the pandemic.
Databáze:	MEDLINE
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