Decoding the connection between lncRNA and obesity: Perspective from humans and Drosophila .

Autor:	Dayal Aggarwal D; Department of Biochemistry, University of Delhi South Campus, New Delhi, India., Mishra P; Department of Biochemistry, University of Delhi South Campus, New Delhi, India., Yadav G; Department of Biochemistry, University of Delhi South Campus, New Delhi, India., Mitra S; Department of Biochemistry, University of Delhi South Campus, New Delhi, India., Patel Y; Department of Zoology, Banaras Hindu University, Varanasi, India., Singh M; Department of Biotechnology, UIET, MD University, Rohtak, India., Sahu RK; Department of Neurology, Houston Methodist Research Insititute, Houston, Tx, USA., Sharma V; Department of Biomedical Sciences, University of Windsor, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2024 Jul 28; Vol. 10 (15), pp. e35327. Date of Electronic Publication: 2024 Jul 28 (Print Publication: 2024).
DOI:	10.1016/j.heliyon.2024.e35327
Abstrakt:	Background: Obesity is a burgeoning global health problem with an escalating prevalence and severe implications for public health. New evidence indicates that long non-coding RNAs (lncRNAs) may play a pivotal role in regulating adipose tissue function and energy homeostasis across various species. However, the molecular mechanisms underlying obesity remain elusive. Scope of Review: This review discusses obesity and fat metabolism in general, highlighting the emerging importance of lncRNAs in modulating adipogenesis. It describes the regulatory networks, latest tools, techniques, and approaches to enhance our understanding of obesity and its lncRNA-mediated epigenetic regulation in humans and Drosophila . Major Conclusions: This review analyses large datasets of human and Drosophila lncRNAs from published databases and literature with experimental evidence supporting lncRNAs role in fat metabolism. It concludes that lncRNAs play a crucial role in obesity-related metabolism. Cross-species comparisons highlight the relevance of Drosophila findings to human obesity, emphasizing their potential role in adipose tissue biology. Furthermore, it discusses how recent technological advancements and multi-omics data integration enhance our capacity to characterize lncRNAs and their function. Additionally, this review briefly touches upon innovative methodologies like experimental evolution and advanced sequencing technologies for identifying novel genes and lncRNA regulators in Drosophila , which can potentially contribute to obesity research. Competing Interests: There are no financial, professional, or personal affiliations that could be perceived as influencing the research presented in this review manuscript. (© 2024 Published by Elsevier Ltd.)
Databáze:	MEDLINE
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