Safety of Atypical Antipsychotics in a Child and Adolescent Inpatient Setting: A Naturalistic Study.
| Autor: | Burak Baykara H; Department of Child and Adolescent Psychiatry, Dokuz Eylül University, Faculty of Medicine, Izmir, Türkiye., Alşen Güney S; Department of Child and Adolescent Psychiatry, Dokuz Eylül University, Faculty of Medicine, Izmir, Türkiye., Avcil S; Department of Child and Adolescent Psychiatry, Aydın Adnan Menderes University, Faculty of Medicine, Aydın, Türkiye., Buran BŞ; Department of Child and Adolescent Psychiatry, Balıkesir Atatürk City Hospital, Balıkesir, Türkiye., Ogulcan Cıray R; Department of Child and Adolescent Psychiatry, Mardin Training And Research Hospital, Mardin, Türkiye., Ermis C; Department of Child and Adolescent Psychiatry, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Göteborg, Sweden., Inal N; Department of Child and Adolescent Psychiatry, Dokuz Eylül University, Faculty of Medicine, Izmir, Türkiye. |
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| Jazyk: | angličtina |
| Zdroj: | Psychiatry and clinical psychopharmacology [Psychiatry Clin Psychopharmacol] 2024 Jun 01; Vol. 34 (2), pp. 109-118. Date of Electronic Publication: 2024 Jun 01 (Print Publication: 2024). |
| DOI: | 10.5152/pcp.2024.23726 |
| Abstrakt: | Background: This study's objective was to investigate the adverse effects of atypical antipsychotics (AAPs) on the metabolic, hematological, and endocrinological systems in the inpatient environment for children and adolescents with diverse psychiatric disorders. Methods: A retrospective assessment of 208 children's and adolescents' medical records was conducted. All patients were on AAP monotherapy. At baseline and after treatment, measurements of body weight, height, body mass index (BMI), BMI z-score, fasting blood glucose (FBG), total cholesterol, low-density lipoprotein cholesterol, triglycerides, high-density lipoprotein cholesterol, complete blood count, liver functions, thyroid functions, and prolactin levels were made. Scores from the Children's Global Assessment Scale (CGAS) and the Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA) were preserved. Results: The overall patient population had a mean age of 14.50 ± 2.32 years, 139 girls, and 69 boys. Of the patients, 63 (30.29%) were on risperidone (RIS), 69(33.17%) were on aripiprazole (ARI), 32 (15.39%) were on quetiapine (QUE), 42 (20.19%) were on olanzapine (OLA), and 2 (0.96%) were on clozapine (CLO). In the OLA group, the BMI and BMI z-score increased more than in the RIS, QUE, and ARI groups ( P = .030, P = .014, and P = .001, respectively) ( P = .001). The mean difference in CGAS and HoNOSCA between the start of antipsychotic medication and hospital discharge was statistically different for all four groups ( P = .001 for all). The mean FBG levels in the OLA group increased statistically significantly ( P = .013, P = .021) in contrast to the RIS group. In addition, a statistically significant difference in triglycerides across the groups was found ( P = .003). Conclusion: According to the findings of our study, children and adolescents appear to be at a significant risk for psychotropic-induced PRL increase, weight gain, metabolic, and hematological consequences. To prevent serious health problems, a meticulous risk-benefit assessment for AAPs treatment should be done between clinicians and patients and their families. Competing Interests: Declaration of Interests: The authors have no conflict of interest to declare. (2024 authors.) |
| Databáze: | MEDLINE |
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