Sublingually administered bacterial lysates: rationale, mechanisms of action and clinical outcomes.
| Autor: | Braido F; IRCCS Ospedale Policlinico San Martino, Italy.; Università di Genova, DiMI, Genoa, Italy., Melioli G; Alliance Medical Diagnostic, Genova, Italy., Nicolini G; Bruschettini srl, Genova, Italy., Ferraris M; Università di Genova, DiMI, Genoa, Italy., Di Girolamo S; Otorhinolaryngology Department of Clinical Science and Translational Medicine, Tor Vergata School of Medicine and Surgery, Rome, Italy., Di Gioacchino M; Center for Advanced Studies and Technology, G. d'Annunzio University, Chieti, Italy.; Institute for Clinical Immunotherapy and Advanced Biological Treatments, Pescara, Italy., Canonica GW; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Asthma & Allergy Unit-IRCCS Humanitas Research Hospital, Milan, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | Drugs in context [Drugs Context] 2024 Aug 07; Vol. 13. Date of Electronic Publication: 2024 Aug 07 (Print Publication: 2024). |
| DOI: | 10.7573/dic.2024-1-5 |
| Abstrakt: | This review discusses available evidence on the mechanisms of action of bacterial lysates, and the clinical effects of their sublingual administration. Bacterial lysates act through many immunological effects, including dendritic cell activation, modification of circulating lymphocyte subsets and antibody production. The production of salivary IgA was repeatedly shown to be induced by the sublingual administration of a prototype bacterial lysate containing soluble and corpuscular antigens. Bacterial lysates are a useful tool for the prevention of recurrent respiratory tract infections. Sublingual administration should be the preferred option. Competing Interests: Disclosure and potential conflicts of interest: GN is the Medical Director of Bruschettini srl, Genova, Italy; GM and FB act as consultant advisors of Bruschettini srl, Genova, Italy; SDG, MDG, MF and GWC have no competing interests. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2024/06/dic.2024-1-5-COI.pdf (Copyright © 2024 Braido F, Melioli G, Nicolini G, Ferraris M, Di Girolamo S, Di Gioacchino M, Canonica GW.) |
| Databáze: | MEDLINE |
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