| Autor: |
Vidal-Gutiérrez M; Departamento de Ciencias Químico Biológicas, Universidad de Sonora, Centro, Hermosillo Sonora, México.; Departamento de Ciencias Químico Biológicas y Agropecuarias, Universidad de Sonora, Navojoa, Sonora, CP, México., Torres-Moreno H; Departamento de Ciencias Químico Biológicas y Agropecuarias, Universidad de Sonora - Avenida Universidad e Irigoyen, Caborca Sonora, CP, México., Arenas-Luna VM; Facultad de Ciencias de la Salud, Escuela de Medicina, Universidad Panamericana, Ciudad de México, CP, México., Loredo-Mendoza ML; Facultad de Ciencias de la Salud, Escuela de Medicina, Universidad Panamericana, Ciudad de México, CP, México., Tejeda-Dominguez F; Facultad de Ciencias de la Salud, Escuela de Medicina, Universidad Panamericana, Ciudad de México, CP, México., Velazquez C; Departamento de Ciencias Químico Biológicas, Universidad de Sonora, Centro, Hermosillo Sonora, México., Vilegas W; Universidade Estadual Paulista (UNESP), Coastal Campus of São Vicente, São Paulo, CEP, Brazil., Hernandez-Gutiérrez S; Facultad de Ciencias de la Salud, Escuela de Medicina, Universidad Panamericana, Ciudad de México, CP, México., Robles-Zepeda RE; Departamento de Ciencias Químico Biológicas, Universidad de Sonora, Centro, Hermosillo Sonora, México. |
| Abstrakt: |
Cucurbitacin IIb, a triterpene obtained from the Ibervillea sonorae plant, reduces tumour development in a preclinical model of cervical cancer. Acetison and Etanison, phytopreparations made from I. sonorae , present biological activity analogous to CIIb in HeLa. This research evaluated the tumour growth inhibitory effect of these phytopreparations in a HeLa xenograft tumour model in BALB/c nude mice. Tumours in mice were treated every 3 days for 12 days with cisplatin (2 mg/kg), CIIb (5 mg/kg), Acetison (20 mg/kg), Etanison (30 mg/kg), and DMSO at 2%. For histological observations, tumours were stained with H&E. Fingerprinting of both phytopreparations was performed using HPLC-UV and UHPLC-APCI-IT-MS. Both phytopreparations and CIIb inhibit tumour development as well as Cisplatin (75.5%); Etanison (77.7%), Acetison (73.6%), and CIIb (73.0%). Furthermore, only tumours treated with cisplatin showed invasion of bone tissue. The results show the potential use of I. sonorae phytopreparations in the treatment of cervical cancer. |
