Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology.

Autor: Zununi Vahed S; Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Hosseiniyan Khatibi SM; Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Ardalan M; Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Jazyk: angličtina
Zdroj: Medicinal research reviews [Med Res Rev] 2025 Jan; Vol. 45 (1), pp. 144-163. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1002/med.22074
Abstrakt: Glomerulonephritis (GN) is an important cause of renal inflammation resulting from kidney-targeted adaptive and innate immune responses and consequent glomerular damage. Given the lack of autoantibodies, immune complexes, or the infiltrating immune cells in some forms of GN, for example, focal segmental glomerulosclerosis and minimal change disease, along with paraneoplastic syndrome and a special form of renal involvement in some viral infections, the likeliest causative scenario would be secreted factors, mainly cytokine(s). Since cytokines can modulate the inflammatory mechanisms, severity, and clinical outcomes of GN, it is rational to consider the umbrella term of cytokine GN as a new outlook to reclassify a group of previously known GN. We focus here, particularly, on cytokines that have the central "canonical effect" in the development of GN.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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