Targeting 8-oxoguanine DNA glycosylase-1 (OGG1 ) as a therapeutic strategy in inflammatory-related diseases.

Autor:	Samaila A; Department of Human Anatomy, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia.; Department of Pharmacology, College of Health Sciences, Umaru Musa Yar'adua University, Katsina, Nigeria., Basir R; Department of Human Anatomy, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia., Gambo Lawal M; Department of Microbiology, Umaru Musa Yar'adua University, Katsina, Nigeria., Abas R; Department of Human Anatomy, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia., Abdullah MA; Department of Pathology, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia., Abd Majid R; Department of Pre-clinical, Faculty of Medicine and Defence Health, National Defence University of Malaysia, Kuala Lumpur, Malaysia., Nordin N; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia., Hussain MK; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia., Ab Razak NI; Department of Human Anatomy, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia., Yoke Keong Y; Department of Human Anatomy, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia., Aliyu B; Department of Microbiology, Federal University Birnin Kebbi, Kebbi, Nigeria.
Jazyk:	angličtina
Zdroj:	Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2024 Oct; Vol. 46 (5), pp. 685-694. Date of Electronic Publication: 2024 Aug 20.
DOI:	10.1080/08923973.2024.2391471
Abstrakt:	Objective: Inflammatory diseases are influenced by oxidative stress. Oxidatively damaged 8-oxoG in DNA is linked to inflammation. The enzyme OGG1 is responsible for repairing the damaged base in the DNA which is linked to pro-inflammatory signaling and severe inflammation. This study aims to explore the potential of targeting OGG1 as a therapeutic strategy in inflammatory disease conditions. Methods: A comprehensive search and review of literature were conducted using appropriate scientific databases such as Google Scholar, Scopus, PubMed, Web of Science, and other references to obtain relevant information that suited the title and content of this article. Results: Compelling pieces of evidence from many previous studies have shown the crucial role of the OGG1/8oxoG pathway in inflammatory disease conditions, leading to severe inflammatory response and death. Therefore, based on these pieces of evidence, targeting this enzyme (OGG1) using specific pharmacological inhibitors or interventions might lead to downregulation and amelioration of severe inflammation to reduce the morbimortality related to several disease conditions. Conclusion: This review highlighted the molecular mechanism of OGG1 activity via the 8-oxo/OGG1 pathway and its role in inflammation and inflammatory disease conditions. Due to the paucity of studies involving OGG1in inflammatory infectious diseases, further research projects are needed to explore the therapeutic potential of various OGG1 inhibitors to serve as novel therapeutic strategies in infectious inflammatory diseases of medical importance in developing countries such as malaria, meningitis, tuberculosis among others.
Databáze:	MEDLINE
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