Characteristics and Outcomes of Fetal Cardiac Rhabdomyoma With or Without mTOR Inhibitors, a Systematic Review and Meta-Analysis.

Autor: Mustafa HJ; The Fetal Center at Riley Children's and Indiana University Health, Division of Maternal-Fetal Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA., Javinani A; Maternal Fetal Care Center, Division of Fetal Medicine and Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Morning ML; Department of Obstetric and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA., D'Antonio F; Center for Fetal Care and High-Risk Pregnancy, Department of Obstetrics and Gynecology, University Hospital of Chieti, Chieti, Italy., Pagani G; Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology, ASST-Papa Giovanni XXIII, Bergamo, Italy., Puranik PM; Pediatric Cardiology, Riley Hospital for Children and Indiana University School of Medicine, Indianapolis, Indiana, USA., Khalil A; Fetal Medicine Unit, St George's Hospital, St George's University of London, London, UK., Shamshirsaz AA; Maternal Fetal Care Center, Division of Fetal Medicine and Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jazyk: angličtina
Zdroj: Prenatal diagnosis [Prenat Diagn] 2024 Sep; Vol. 44 (10), pp. 1251-1267. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1002/pd.6640
Abstrakt: Objectives: To investigate the characteristics and outcomes of fetal cardiac rhabdomyoma with or without prenatal use of mammalian target of rapamycin inhibitor (mTORi).
Search Strategy: We systematically searched PubMed, Scopus, and Web of Science until June 2023.
Selection Criteria: Studies reporting on pregnancies with fetal cardiac rhabdomyoma were included.
Data Collection and Analysis: A meta-analysis of proportions was conducted only on studies that included three or more cases.
Results: A systematic review included 61 studies reporting on 400 fetuses with cardiac rhabdomyoma, of which 52 studies (389 fetuses) had expectant management and 9 studies (11 fetuses) were managed with mTORi. The meta-analysis included 26 studies reporting on 354 fetuses. Prenatally, 14% (95% CI 4-36) had pericardial effusion, 13% (95% CI 6-27) had arrhythmia, 16% (95% CI 7-31) had outflow tract obstruction, and 10% (95% CI 4-21) had hydrops. Fetal demise occurred in 12% (95% CI 5-30). Before delivery, tumor size reduction was noted in 13%, and after birth in 58%. Following birth, 8% (95% CI 3-14) had neonatal death and 9% (95% 4-17) required cardiac surgery. 60% (95% CI 41-79) of cases were diagnosed with tuberous sclerosis. Seizures were reported only in cases with a tuberous sclerosis diagnosis (41/71 infants). For the 9 studies reporting all together on 11 fetuses with tuberous sclerosis receiving prenatal mTORi, they showed improvement in the size of cardiac rhabdomyoma as well as outflow obstruction and none had fetal demise or neonatal death, and none required postnatal cardiac surgery.
Conclusions: We report on the natural history of prenatal cardiac rhabdomyoma, including characteristics, progression, and survival. We report 11 fetuses with tuberous sclerosis and cardiac rhabdomyoma receiving prenatal mTORi, showing promising results.
(© 2024 The Author(s). Prenatal Diagnosis published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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