Influenza vaccination stimulates maturation of the human T follicular helper cell response.

Autor: Schattgen SA; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Turner JS; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Ghonim MA; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Crawford JC; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Schmitz AJ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Kim H; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Zhou JQ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Awad W; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Mettelman RC; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Kim W; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Microbiology, Korea University College of Medicine, Seoul, Korea., McIntire KM; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Haile A; Clinical Trials Unit, Washington University School of Medicine, St. Louis, MO, USA., Klebert MK; Clinical Trials Unit, Washington University School of Medicine, St. Louis, MO, USA., Suessen T; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Middleton WD; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Teefey SA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Presti RM; Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA., Ellebedy AH; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. ellebedy@wustl.edu.; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. ellebedy@wustl.edu.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA. ellebedy@wustl.edu., Thomas PG; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA. paul.thomas@stjude.org.
Jazyk: angličtina
Zdroj: Nature immunology [Nat Immunol] 2024 Sep; Vol. 25 (9), pp. 1742-1753. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1038/s41590-024-01926-6
Abstrakt: The differentiation and specificity of human CD4 + T follicular helper cells (T FH cells) after influenza vaccination have been poorly defined. Here we profiled blood and draining lymph node (LN) samples from human volunteers for over 2 years after two influenza vaccines were administered 1 year apart to define the evolution of the CD4 + T FH cell response. The first vaccination induced an increase in the frequency of circulating T FH (cT FH ) and LN T FH cells at week 1 postvaccination. This increase was transient for cT FH cells, whereas the LN T FH cells further expanded during week 2 and remained elevated in frequency for at least 3 months. We observed several distinct subsets of T FH cells in the LN, including pre-T FH cells, memory T FH cells, germinal center (GC) T FH cells and interleukin-10 + T FH cell subsets beginning at baseline and at all time points postvaccination. The shift toward a GC T FH cell phenotype occurred with faster kinetics after the second vaccine compared to the first vaccine. We identified several influenza-specific T FH cell clonal lineages, including multiple responses targeting internal influenza virus proteins, and found that each T FH cell state was attainable within a clonal lineage. Thus, human T FH cells form a durable and dynamic multitissue network.
(© 2024. The Author(s).)
Databáze: MEDLINE
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