A Perspective on Evaluating Life Stage Differences in Drug Dosages for Drug Labeling and Instructions.

Autor: Gu T; Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, Tennesse, 38103, USA.; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, PR China., Wang G; General Surgery, The 2nd Hospital of Hebei Medical University, 215 Heping Road, Shijiazhuang, Hebei, China., van den Oord EJC; Center for Biomarker Research and Precision Medicine (BPM), Virginia Commonwealth University, VCU Health Sciences Research Building, Room 216A, P. O. Box 980533, Richmond, Virgina, 23298-0581, USA., Goldman E; Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey, 07103, USA., Yang C; Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Centre, Memphis, Tennesse, 38163, USA., Xie N; College of Business, University of Louisville, Louisville, Kentucky, 40292, USA., Yao L; Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Centre, Memphis, Tennesse, 38163, USA.; College of Health Management, Harbin Medical University, 157 Baojian Road, Harbin, 150081, Heilongjiang, China., Wang CY; The Centre for Biomedical Research, Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Jablonski M; Department of Ophthalmology, University of Tennessee Health Sciences Center, Memphis, Tennesse, USA.; Department of Medicine, University of Tennessee Health Sciences Center, Memphis, Tennesse, USA.; Hamilton Eye Institute, University of Tennessee Health Sciences Center, Memphis, Tennesse, USA.; College of Nursing, University of Tennessee Health Science Center, Memphis, Tennesse, 38105, USA., Ray K; School of Biological Science, Ramkrishna Mission Vivekananda Education & Research Institute, Narendrapur, 700103, West Bengal, India., Liu F; Research Center, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050011, China., Pan W; Respiratory Medicine and Intensive Care, The 2, Hospital of Hebei Medical University, 215 Heping Road, Shijiazhuang, Hebei, China., Flores G; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, San Manuel, 72570, Puebla, Mexico., Aleya L; Chrono-Environnement Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, 25030, Besançon Cedex, France., Meng X; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, PR China., Jiao Y; Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Centre, Memphis, Tennesse, 38163, USA., Li M; Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, Tennesse, 38103, USA. mli54@uthsc.edu.; Memphis, USA. mli54@uthsc.edu., Wang Y; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, PR China. Yongjunwang1962@gmail.com.; Department of Neurology and Department of Clinical Trial Center, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China. Yongjunwang1962@gmail.com., Gu W; Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Centre, Memphis, Tennesse, 38163, USA. wgu@uthsc.edu.; Lt. Col. Luke Weathers, Jr. VA Medical Center, 116 N Pauline St., Memphis, Tennesse, 38105, USA. wgu@uthsc.edu.; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 956 Court Avenue, Memphis, Tennesse, 38163, USA. wgu@uthsc.edu.
Jazyk: angličtina
Zdroj: The AAPS journal [AAPS J] 2024 Aug 20; Vol. 26 (5), pp. 95. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1208/s12248-024-00964-0
Abstrakt: Drug labeling and instructions provide essential information for patients regarding the usage of drugs. Instructions for the dosage of drug usage are critical for the effectiveness of the drug and the safety of patients. The dosage of many drugs varies depending on the patient's age. However, as our understanding of human biology deepens, we believe that these instructions need to be modified to incorporate different life stages. This is because human biology and metabolism differ significantly among different life stages, and their responses to drugs also vary. Additionally, the same age of different persons may fall into different life stages. Therefore, our group from multiple institutes and countries proposes a reexamination of whether incorporating life stages in all or any drug instructions will greatly enhance drug efficiency and patients' health.
(© 2024. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.)
Databáze: MEDLINE
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