Serological indication of chronic inflammatory demyelinating polyneuropathy as an extrahepatic manifestation of hepatitis E virus infection.

Autor: Pischke S; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany. s.pischke@uke.de.; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Partner Site, Hamburg, Germany. s.pischke@uke.de., Kjasimov A; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany., Skripuletz T; Department of Neurology, Hannover Medical School, Hannover, Germany., Casar C; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany., Bannasch J; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Partner Site, Hamburg, Germany.; Institute for Microbiology and Hygiene, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Mader M; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany., Huber S; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany., Konen F; Department of Neurology, Hannover Medical School, Hannover, Germany., Wolski A; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany., Horvatits T; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Partner Site, Hamburg, Germany., Gingele S; Department of Neurology, Hannover Medical School, Hannover, Germany., Peine S; Institute of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hiller J; Institute of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Seeliger T; Department of Neurology, Hannover Medical School, Hannover, Germany., Thayssen G; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Lütgehetmann M; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Partner Site, Hamburg, Germany.; Institute for Microbiology and Hygiene, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Schulze Zur Wiesch J; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Partner Site, Hamburg, Germany., Golsari A; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Gelderblom M; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Aug 20; Vol. 14 (1), pp. 19244. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1038/s41598-024-70104-3
Abstrakt: Guillain-Barré syndrome and neuralgic amyotrophy have been associated with hepatitis E virus (HEV) genotype 3 infections, while myasthenia gravis (MG) has been associated with HEV genotype 4 infections. However, whether chronic inflammatory demyelinating polyneuropathy (CIDP) is associated with HEV infections has not been conclusively clarified yet. 102 CIDP patients, 102 age- and sex-matched blood donors, 61 peripheral neuropathy patients (non-CIDP patients), and 26 MG patients were tested for HEV and anti-HEV IgM and IgG. Sixty-five of the 102 (64%) CIDP patients tested positive for anti-HEV IgG and one (1%) for anti-HEV IgM. No other patient tested positive for ati-HEV IgM. In the subgroup of CIDP patients with initial diagnosis (without previous IVIG treatment), 30/54 (56%) tested positive for anti-HEV IgG. Anti-HEV rates were significantly lower in blood donors (28%), non-CIDP peripheral neuropathy patients (20%), and MG patients (12%). No subject tested positive for HEV viremia. CSF tested negative for in 61 CIDP patients (54 patients with primary diagnosis). The development of CIDP but not non-CIDP polyneuropathy may be triggered by HEV exposure in an HEV genotype 3 endemic region. The increased anti-HEV seroprevalence in CIDP patients is not a consequence of IVIG therapy.
(© 2024. The Author(s).)
Databáze: MEDLINE
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