Microneedle patch casting using a micromachined carbon master for enhanced drug delivery.

Autor: Choi HJ; School of Mechanical Engineering, Kyungpook National University, Daegu, 41566, South Korea., Ullah A; Department of Mechanical Engineering, University of Engineering and Technology, Mardan, Khyber Pakhtunkhwa, 23200, Pakistan., Jang MJ; Preclinical Research Center, Daegu Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea., Lee US; Department of Mechanical Engineering, Graduate School, Soongsil University, 369 Sangdo-ro, Dongjak-gu, Seoul, 06978, Republic of Korea., Shin MC; School of Mechanical Engineering, Kyungpook National University, Daegu, 41566, South Korea., An SH; Preclinical Research Center, Daegu Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea., Kim D; Preclinical Research Center, Daegu Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea., Kim BH; School of Mechanical Engineering, Soongsil University, Seoul, 06978, South Korea. bhkim@ssu.ac.kr., Kim GM; School of Mechanical Engineering, Kyungpook National University, Daegu, 41566, South Korea. gyuman.kim@knu.ac.kr.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Aug 20; Vol. 14 (1), pp. 19228. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1038/s41598-024-70393-8
Abstrakt: For successful treatment of diseases, sufficient therapeutics must be provided to the body. Microneedle applications in therapeutic delivery and analytics sampling are restricted because of various issues, including smaller area for drug loading and analytics sampling. To achieve sufficient drug loading and analytics sampling and improve drug penetration while maintaining painless administration, patch-type microneedle arrays were designed and fabricated using polymer casting from a conical cavity mold. Microcavities were formed on a carbon plate via micromechanical machining. A porous polymer layer was coated on a microneedle patch (MNP). The pores of the porous polymer layer provided space and channels for drug delivery. A pH-sensitive polymer layer was employed to cap the porous polymer layer, which prevented drug leakage during storage and provided a stimulus drug release in response to body pH conditions. The drug can be delivered through holes connected to both sides of the patch. The drug release of the MNP was investigated in vitro and in vivo and showed conceptual proof that these MNs have the potential to enhance treatment protocols for various diseases with the flexibility of coating and therapeutic materials and offer significant scope for further variations and advancement.
(© 2024. The Author(s).)
Databáze: MEDLINE
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