Non-human primate model of long-COVID identifies immune associates of hyperglycemia.

Autor: Palmer CS; Tulane National Primate Research Center, Covington, LA, USA. cpalmer3@tulane.edu.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA. cpalmer3@tulane.edu., Perdios C; Tulane National Primate Research Center, Covington, LA, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA., Abdel-Mohsen M; The Wistar Institute, Philadelphia, PA, USA., Mudd J; Tulane National Primate Research Center, Covington, LA, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA., Datta PK; Tulane National Primate Research Center, Covington, LA, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA., Maness NJ; Tulane National Primate Research Center, Covington, LA, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA., Lehmicke G; Tulane National Primate Research Center, Covington, LA, USA., Golden N; Tulane National Primate Research Center, Covington, LA, USA., Hellmers L; Tulane National Primate Research Center, Covington, LA, USA., Coyne C; Tulane National Primate Research Center, Covington, LA, USA., Moore Green K; Tulane National Primate Research Center, Covington, LA, USA., Midkiff C; Tulane National Primate Research Center, Covington, LA, USA., Williams K; Tulane National Primate Research Center, Covington, LA, USA., Tiburcio R; Division of Experimental Medicine, Department of Medicine, University of San Francisco, CA, USA., Fahlberg M; Tulane National Primate Research Center, Covington, LA, USA., Boykin K; Tulane National Primate Research Center, Covington, LA, USA., Kenway C; Tulane National Primate Research Center, Covington, LA, USA., Russell-Lodrigue K; Tulane National Primate Research Center, Covington, LA, USA.; Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA., Birnbaum A; Tulane National Primate Research Center, Covington, LA, USA., Bohm R; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA., Blair R; Tulane National Primate Research Center, Covington, LA, USA.; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, USA., Dufour JP; Tulane National Primate Research Center, Covington, LA, USA.; Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA., Fischer T; Tulane National Primate Research Center, Covington, LA, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA., Saied AA; Tulane National Primate Research Center, Covington, LA, USA.; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, USA., Rappaport J; Tulane National Primate Research Center, Covington, LA, USA. jrappaport@tulane.edu.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA. jrappaport@tulane.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Aug 20; Vol. 15 (1), pp. 6664. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1038/s41467-024-50339-4
Abstrakt: Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations of the post-acute sequelae of SARS-CoV-2. Our understanding of metabolic decline after acute COVID-19 remains unclear due to the lack of animal models. Here, we report a non-human primate model of metabolic post-acute sequelae of SARS-CoV-2 using SARS-CoV-2 infected African green monkeys. Using this model, we identify a dysregulated blood chemokine signature during acute COVID-19 that correlates with elevated and persistent hyperglycemia four months post-infection. Hyperglycemia also correlates with liver glycogen levels, but there is no evidence of substantial long-term SARS-CoV-2 replication in the liver and pancreas. Finally, we report a favorable glycemic effect of the SARS-CoV-2 mRNA vaccine, administered on day 4 post-infection. Together, these data suggest that the African green monkey model exhibits important similarities to humans and can be utilized to assess therapeutic candidates to combat COVID-related metabolic defects.
(© 2024. The Author(s).)
Databáze: MEDLINE
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