Systematic Review and Meta-Analysis of the Outcomes After Hepatic Artery Reconstruction in Pediatric Liver Transplantation Using a Microscope Versus Surgical Loupe.

Autor: Koh ZJ; Department of Paediatric Surgery, National University Hospital, Singapore, Singapore. Electronic address: zong_jie_koh@nuhs.edu.sg., Wu AG; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Yew A; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lee YY; Department of Paediatric Surgery, National University Hospital, Singapore, Singapore., Loh DL; Department of Paediatric Surgery, National University Hospital, Singapore, Singapore., Nyo YL; Department of Paediatric Surgery, National University Hospital, Singapore, Singapore., Mali VP; Department of Paediatric Surgery, National University Hospital, Singapore, Singapore.
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2024 Sep; Vol. 56 (7), pp. 1585-1592. Date of Electronic Publication: 2024 Aug 19.
DOI: 10.1016/j.transproceed.2024.08.019
Abstrakt: Background: To review the impact of the operating microscope (OM) for reconstruction of the hepatic artery (HA) by comparing the outcomes with standard loupe reconstruction (SL) in pediatric liver transplantation (LT).
Methods: Studies comparing the application of OM and SL for the reconstruction of the HA in primary pediatric LT were included from a systematic search of MEDLINE, Cochrane Library and EMBASE from inception to June 2022. Re-transplantation, dual grafts and auxiliary transplants were excluded. Primary outcome was the rate of HA thrombosis (HAT). Secondary outcomes were graft loss and mortality.
Results: There were 1261 liver recipients from 9 included studies published until June 2022. There were 484 patients in the OM group and 777 patients in the SL group. HAT incidence with OM was significantly lower with OR = 0.18 (95% CI: 0.07-0.48). The 1-year graft survival was significantly better in the OM group with OR = 2.77 (95% CI: 1.13-6.80). 1-year overall mortality was also significantly lower with OM with OR = 0.39 (0.18-0.86). The use of OM did not significantly impact the incidence of HAT in the living donor liver transplant subgroup. Differences in time for hepatic HA reconstruction, total operating time and length of hospital stay did not reach statistical significance.
Conclusion: The use of OM has reduced the risk of HAT, graft loss and mortality in pediatric liver transplantation. Adoption of microsurgical principles in general may have contributed to the improved outcomes with SL reconstruction of HA in pediatric LT.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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