Venous thromboembolic events associated with blood product administration in an era of whole blood use.

Autor: Schauer SG; Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA; Center for Combat and Battlefield (COMBAT) Research, University of Colorado School of Medicine, Aurora, CO, USA; Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Electronic address: steven.schauer@cuanschutz.edu., April MD; Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Fisher AD; Department of Surgery, University of New Mexico School of Medicine, Albuquerque, NM, USA., Wright FL; Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA., Cohen MJ; Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA., Getz TM; Center for Combat and Battlefield (COMBAT) Research, University of Colorado School of Medicine, Aurora, CO, USA., Rizzo JA; Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Brooke Army Medical Center, JBSA Fort Sam Houston, Texas, USA., Winkle JM; Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA., Braverman MA; Division of Trauma and Emergency Surgery, Department of Surgery, UT Health San Antonio, San Antonio, TX, USA; Division of Acute Care Surgical Services, Department of Surgery, St. Luke's University Health Network, Bethlehem, PA, USA.
Jazyk: angličtina
Zdroj: American journal of surgery [Am J Surg] 2024 Aug 03; Vol. 238, pp. 115887. Date of Electronic Publication: 2024 Aug 03.
DOI: 10.1016/j.amjsurg.2024.115887
Abstrakt: Background: The risks associated with blood product administration and venous thromboembolic events remains unclear. We sought to determine which blood products were associated with the development of deep vein thrombosis (DVT) and pulmonary embolism (PE).
Methods: We analyzed data from patients ≥18 years of age in the Trauma Quality Improvement Program (TQIP) database that received ≥1 blood product and survived ≥24 ​h.
Results: There were 42,399 that met inclusion, of whom, 2086 had at least one VTE event. In our multivariable logistic regression model, we found that WB had a unit odds ratio (uOR) of 1.05 (95 ​% CI 1.02-1.08) for DVT and 1.08 (1.05-1.12) for PE. Compared to WB, platelets had a higher uOR for DVT of 1.09 (1.04-1.13) but similar uOR for PE of 1.08 (1.03-1.14).
Conclusions: We found an association of both DVT and PE with early whole blood and platelets.
Competing Interests: Declaration of competing interest SGS, MDA, ADF, FLW, MJC, TMG, and JAR have all received support from the Department of Defense in the form of grant funds to their institution. FLW, MJC, and TMG have received salary support from the Department of Defense in the form of grants. JMW has received travel funding support from the Society of Critical Care Medicine as part of her committee duties. MJC has received support from the National Institutes of Health in the form of grants. We have no commercial funds to report.
(Published by Elsevier Inc.)
Databáze: MEDLINE
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