Academic readiness among young children treated for brain tumors: a multisite, prospective, longitudinal trial.

Autor:	Somekh MR; Department of Psychology and Biobehavioral Sciences, St Jude Children's Research Hospital, Memphis, TN, USA., Ashford JM; Department of Psychology and Biobehavioral Sciences, St Jude Children's Research Hospital, Memphis, TN, USA., Swain MA; Oncology Services Group, Queensland Children's Hospital, Brisbane, QLD, Australia., Harder LL; Departments of Psychiatry and Neurology, Children's Medical Center Dallas, Dallas, TX, USA., Carlson-Green BL; Department of Pediatric Neuropsychology, Children's Minnesota, Minneapolis, MN, USA., Wallace J; Neuropsychology, Child Neurology, Lucile Packard Children's Hospital Stanford, Palo Alto, CA, USA., Kaner RJ; Cancer and Blood Disorders, Rady Children's Hospital, San Diego, CA, USA., Billups CA; Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN, USA., Onar-Thomas A; Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN, USA., Ali JS; Mental Health Patient Services Unit, The Children's Hospital of Eastern Ontario, Toronto, ON, Canada., Harman JL; Department of Psychology and Biobehavioral Sciences, St Jude Children's Research Hospital, Memphis, TN, USA., Merchant TE; Department of Radiation Oncology, St Jude Children's Research Hospital, Memphis, TN, USA., Gajjar A; Department of Pediatric Medicine, Neuro-Oncology Division, St Jude Children's Research Hospital, Memphis, TN, USA., Conklin HM; Department of Psychology and Biobehavioral Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Jazyk:	angličtina
Zdroj:	Journal of the National Cancer Institute [J Natl Cancer Inst] 2024 Dec 01; Vol. 116 (12), pp. 1952-1960.
DOI:	10.1093/jnci/djae194
Abstrakt:	Background: Young children treated for central nervous system (CNS) malignancies are at high risk for difficulties with academic functioning due to increased vulnerability of the developing brain and missed early developmental opportunities. Extant literature examining academics in this population is limited. We investigated academic readiness, its clinical and demographic predictors, and its relationship with distal academic outcomes among patients treated for CNS tumors during early childhood. Methods: Seventy patients with newly diagnosed CNS tumors were treated on a prospective, longitudinal, multisite study with chemotherapy, with or without photon or proton irradiation. Patients underwent assessments of academic skills at baseline, 6 months, 1 year, and then annually for 5 years. Assessments measured academic readiness and academic achievement in reading and math. Results: Mixed linear models revealed slowed development of academic readiness skills over time. Socioeconomic status (SES) was predictive of academic readiness at all time points. Other demographic (eg, age at treatment) and clinical (eg, shunt status, treatment exposure) variables were not predictive of academic readiness. Distal reading difficulties were proportionally greater than normative expectations while math difficulties did not differ. Academic readiness was predictive of distal academic outcomes in reading and math. Conclusions: Treatment for CNS malignancies in early childhood appears to slow development of academic readiness skills, with SES predictive of risk. Academic readiness skills were predictive of subsequent academic achievement. A disproportionate number of long-term survivors performed below age-based expectations in reading. These findings suggest the need for monitoring and interventions targeting early academic skills in this population. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu