Long-term Health Outcomes After Hospital Discharge Among Children Hospitalized for MIS-C or COVID-19, September 29, 2021, to June 21, 2022.

Autor:	Godfred-Cato S; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia., Kunkel A; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia., Abrams JY; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia., Shah AB; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.; General Dynamics Information Technology, Falls Church, Virginia., Yousaf A; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia., Hammett TA; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia., Choi JH; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia and Children's Healthcare of Atlanta, Atlanta, Georgia., Perez MA; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia and Children's Healthcare of Atlanta, Atlanta, Georgia., Hsiao HM; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia and Children's Healthcare of Atlanta, Atlanta, Georgia., Rostad CA; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia and Children's Healthcare of Atlanta, Atlanta, Georgia., Laham FR; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.; Division of Pediatric Infectious Diseases, Orlando Health Arnold Palmer Hospital for Children, Orlando, Florida., Kao CM; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.; Division of Pediatric Infectious Diseases, Orlando Health Arnold Palmer Hospital for Children, Orlando, Florida., Hunstad DA; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.; Division of Pediatric Infectious Diseases, Orlando Health Arnold Palmer Hospital for Children, Orlando, Florida., Oster ME; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia., Campbell AP; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia., Belay ED; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.
Jazyk:	angličtina
Zdroj:	The Pediatric infectious disease journal [Pediatr Infect Dis J] 2024 Aug 15. Date of Electronic Publication: 2024 Aug 15.
DOI:	10.1097/INF.0000000000004477
Abstrakt:	Background: The long-term effects of children hospitalized with multisystem inflammatory syndrome in children (MIS-C) or acute COVID-19 are not well known. Our objective was to determine long-term outcomes. Methods: Children hospitalized with MIS-C or COVID-19 at 3 US hospitals from March 2020, through February 2021 were followed to assess health through 2 years post-hospitalization using medical records and patient surveys. Results: Medical record abstraction was performed for 183 patients hospitalized with MIS-C, 53 of whom participated in surveys, and 97 patients hospitalized with COVID-19, 35 of whom participated in surveys. Patients with MIS-C were younger (median, 9 vs. 14 years of age for COVID-19 patients; P = 0.004), more frequently male (62% vs. 39%; P < 0.001) and had more cardiac (14% vs. 2%; P = 0.001) and neurologic sequelae (8% vs. 1%; P = 0.023). Children with COVID-19 more often had other comorbidities (59% vs. 19%; P < 0.001). Full mental recovery at the time of survey 2 (median, 16 months post-hospitalization for patients with MIS-C and 20 months for patients with COVID-19) was 85% and 88%, respectively; full physical recovery was 87% and 81%, respectively; and nearly all had resumption of normal activities. Patients with MIS-C reported more frequent headache at 1 month (45% vs. 20%; P = 0.037). Patients with COVID-19 were more likely to report cough at 1 month (37% vs. 17%; P = 0.045). Fatigue persisted >1 year in 15%-20% of patients in both groups. Conclusions: Approximately 20% of children with MIS-C and COVID-19 continued to have symptoms including fatigue and headache >1 year after hospital discharge. The duration of these findings emphasizes the importance of providers following patients until sequelae have resolved. Competing Interests: S.G.-C.’s institution has received funding to conduct research unrelated to this article from the pediatric pandemic network. C.A.R.’s institution has received funds to conduct clinical research unrelated to this article from the National Institutes of Health (NIH), BioFire, Inc, GlaxoSmithKline, MedImmune, Micron, Janssen, Merck, Moderna, Novavax, PaxVax, Pfizer, Regeneron and Sanofi Pasteur. She is a coinventor of patented respiratory syncytial virus vaccine technology unrelated to this article, which has been licensed to Meissa Vaccines, Inc. Her institution has received funding from NIH to conduct clinical trials of Moderna and Janssen COVID-19 vaccines. F.R.L. received a grant from Lilly for work unrelated to this investigation. D.A.H’s institution received funding from NIH and BioAge Laboratories for research unrelated to this article. He serves on the Board of Directors for BioVersys AG, Switzerland; he also receives stock options from this company. He also serves on the Pediatric Academic Societies, Inc, Society for Pediatric Research and Pediatric Research Foundation. M.E.O.’s institution has received funds from NIH for the evaluation of patients with multisystem inflammatory syndrome in children. The other authors have no other funding or conflicts of interest to disclose. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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