Optogenetic silencing of medial septal GABAergic neurons disrupts grid cell spatial and temporal coding in the medial entorhinal cortex.

Autor:	Robinson JC; Center for Systems Neuroscience, Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA. Electronic address: jenniferclaire.robinson@gmail.com., Ying J; Department of Psychiatry, Douglas Hospital Research Centre, McGill University, Montreal QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada., Hasselmo ME; Center for Systems Neuroscience, Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA., Brandon MP; Department of Psychiatry, Douglas Hospital Research Centre, McGill University, Montreal QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada. Electronic address: mark.brandon@mcgill.ca.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2024 Aug 27; Vol. 43 (8), pp. 114590. Date of Electronic Publication: 2024 Aug 19.
DOI:	10.1016/j.celrep.2024.114590
Abstrakt:	The hippocampus and medial entorhinal cortex (MEC) form a cognitive map that facilitates spatial navigation. As part of this map, MEC grid cells fire in a repeating hexagonal pattern across an environment. This grid pattern relies on inputs from the medial septum (MS). The MS, and specifically GABAergic neurons, are essential for theta rhythm oscillations in the entorhinal-hippocampal network; however, the role of this population in grid cell function is unclear. To investigate this, we use optogenetics to inhibit MS-GABAergic neurons and observe that MS-GABAergic inhibition disrupts grid cell spatial periodicity. Grid cell spatial periodicity is disrupted during both optogenetic inhibition periods and short inter-stimulus intervals. In contrast, longer inter-stimulus intervals allow for the recovery of grid cell spatial firing. In addition, grid cell phase precession is also disrupted. These findings highlight the critical role of MS-GABAergic neurons in maintaining grid cell spatial and temporal coding in the MEC. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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