Precision Interventions Targeting the Maternal Metabolic Milieu for Healthy Pregnancies in Obesity.

Autor: Niclou AM; Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA., Cabre HE; Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA., Flanagan EW; Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA., Redman LM; Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA. Leanne.redman@pbrc.edu.
Jazyk: angličtina
Zdroj: Current diabetes reports [Curr Diab Rep] 2024 Oct; Vol. 24 (10), pp. 227-235. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1007/s11892-024-01550-6
Abstrakt: Purpose of Review: Entering pregnancy with obesity increases the risk of adverse health outcomes for parent and child. As such, research interventions are largely focused on limiting excess gestational weight gain during pregnancy, especially in those with obesity. Yet, while many lifestyle interventions are successful in reducing GWG, few affect pregnancy outcomes. Here we review work targeting the metabolic milieu instead of focusing solely on weight.
Recent Findings: Work done in non-pregnant populations suggests that specifically targeting glucose, triglyceride, and leptin levels or inflammatory makers improves the metabolic milieu and overall health. We posit that precision interventions that include strategies such as time restricted eating, following the 24 h movement guidelines, or reducing sedentary behavior during pregnancy can be successful approaches benefiting the maternal metabolic milieu and minimize the risk of adverse pregnancy outcomes. Personalized tools such as continuous glucose monitors or community-based approaches play an important role in pre-conception health and should be extrapolated to pregnancy interventions to directly benefit the metabolic milieu optimizing health outcomes for both parent and child.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: