MicroRNAs Modulating Neuroinflammation in Parkinson's disease.

Autor: Saadh MJ; Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan., Muhammad FA; Department of Pharmacy, Al-Noor University College, Nineveh, Iraq., Singh A; Department of Biotechnology and Genetics, Jain (Deemed-to-Be) University, Bengaluru, Karnataka, 560069, India.; Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan, 303012, India., Mustafa MA; School of Pharmacy-Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Uttar Pradesh, 247341, India.; Department of Pharmacy, Arka Jain University, Jamshedpur,, Jamshedpur,, India, Jharkhand, 831001., Al Zuhairi RAH; National University of Science and Technology, Dhi Qar, Iraq., Ghildiyal P; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India., Hashim G; Department of Nursing, Al-Zahrawi University College, Karbala, Iraq., Alsaikhan F; College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia. fsaikhan@hotmail.com.; School of Pharmacy, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia. fsaikhan@hotmail.com., Khalilollah S; Department of Neurosurgery, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Akhavan-Sigari R; Department of Neurosurgery, University Medical Center, Tuebingen, Germany.; Department of Health Care Management and Clinical Research, Collegium Humanum Warsaw Management University Warsaw, Warszawa, Poland.
Jazyk: angličtina
Zdroj: Inflammation [Inflammation] 2024 Aug 20. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1007/s10753-024-02125-z
Abstrakt: Parkinson's disease (PD) is one of the most frequent age-associated neurodegenerative disorder. Presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (SNpc) and loss of dopaminergic (DA) neurons are among the characteristic of PD. One of the hallmarks of PD pathophysiology is chronic neuroinflammation. Activation of glial cells and elevated levels of pro-inflammatory factors are confirmed as frequent features of the PD brain. Chronic secretion of pro-inflammatory cytokines by activated astrocytes and microglia exacerbates DA neuron degeneration in the SNpc. MicroRNAs (miRNAs) are among endogenous non-coding small RNA with the ability to perform post-transcriptional regulation in target genes. In that regard, the capability of miRNAs for modulating inflammatory signaling is the center of attention in many investigations. MiRNAs could enhance or limit inflammatory signaling, exacerbating or ameliorating the pathological consequences of extreme neuroinflammation. This review summarizes the importance of inflammation in the pathophysiology of PD. Besides, we discuss the role of miRNAs in promoting or protecting neural cell injury in the PD model by controlling the inflammatory pathway. Modifying the neuroinflammation by miRNAs could be considered a primary therapeutic strategy for PD.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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