Role of induction chemotherapy in advanced-stage olfactory neuroblastoma.

Autor: Cho SW; Department of Otorhinolaryngology, Head and Neck Surgery, Seongnam, South Korea., Keam B; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea., Lee KW; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea., Kim JW; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea., Han DH; Department of Otorhinolaryngology, Head and Neck Surgery, Seoul National University Hospital, Seoul, South Korea., Kim HJ; Department of Otorhinolaryngology, Head and Neck Surgery, Seoul National University Hospital, Seoul, South Korea., Kim JW; Department of Otorhinolaryngology, Head and Neck Surgery, Seongnam, South Korea.; Sensory Organ Research Institute, Seoul National University Medical Research Center, Seoul, South Korea., Kim DY; Department of Otorhinolaryngology, Head and Neck Surgery, Seoul National University Hospital, Seoul, South Korea., Rhee CS; Department of Otorhinolaryngology, Head and Neck Surgery, Seongnam, South Korea.; Sensory Organ Research Institute, Seoul National University Medical Research Center, Seoul, South Korea., Bae YJ; Department of Radiology, Seoul National University Bundang Hospital, Seongnam, South Korea., Kim JH; Department of Radiology, Seoul National University Hospital, Seoul, South Korea., Eom KY; Department of Radiation Oncology, Seoul National University Bundang Hospital, Seongnam, South Korea., Wu HG; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea., Kim YH; Department of Neurosurgery, Seoul National University Hospital, Seoul, South Korea., Kim CY; Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam, South Korea., Paek SH; Department of Neurosurgery, Seoul National University Hospital, Seoul, South Korea., Kim H; Department of Pathology, Seoul National University Bundang Hospital, Seongnam, South Korea., Won TB; Department of Otorhinolaryngology, Head and Neck Surgery, Seongnam, South Korea.; Department of Otorhinolaryngology, Head and Neck Surgery, Seoul National University Hospital, Seoul, South Korea.
Jazyk: angličtina
Zdroj: International forum of allergy & rhinology [Int Forum Allergy Rhinol] 2024 Dec; Vol. 14 (12), pp. 1882-1891. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1002/alr.23428
Abstrakt: Objectives: To evaluate the treatment outcomes in patients with advanced-stage olfactory neuroblastoma (ONB) who received induction chemotherapy (IC).
Materials and Methods: The clinical data of 38 patients with advanced-stage ONB who received initial IC were retrospectively analyzed. The response was defined using the Response Evaluation Criteria in Solid Tumors version 1.1. Patients with complete remission or partial remission were defined as responders.
Results: Seventeen (44.7%) patients responded to IC. The response rate was higher in patients with high Hyams grade tumor (III/IV) compared to those with low-grade tumors (I/II) (60% vs. 22.2%, p = 0.038). Overall, the 5-year cancer-specific survival (CSS) rate was 76.0%. Among nonresponders to IC, a significant difference in 5-year CSS rates was observed between surgery with adjuvant radiotherapy (RT) (100%) versus definitive RT or chemoradiotherapy (CRT) (68.6%) (log-rank p = 0.006). However, for responders, there was no significant difference in 5-year CSS rates between surgery with adjuvant therapy (75%) and definitive RT or CRT (51.1%) (log-rank p = 0.536). When only high-grade tumors were considered among responders, the 5-year CSS rate was significantly higher in patients who received RT or CRT (51.4%) compared to those who underwent surgery with adjuvant therapy (0%) (log-rank p = 0.008).
Conclusion: In advanced-stage ONB, RT or CRT may be preferable for high-grade tumor responding to IC. Higher response rate and a potential role for induction IC in determining the optimal definitive treatment modality suggest a positive role for advanced-stage high-grade ONB.
(© 2024 ARS‐AAOA, LLC.)
Databáze: MEDLINE
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