| Autor: |
Egodawaththa NM; Department of Chemistry and Chemical Engineering, Florida Institute of Technology, Melbourne, Florida 32901, USA. nesnas@fit.edu., Rajhel O; Department of Chemistry and Chemical Engineering, Florida Institute of Technology, Melbourne, Florida 32901, USA. nesnas@fit.edu., Ma J; Department of Chemistry and Chemical Engineering, Florida Institute of Technology, Melbourne, Florida 32901, USA. nesnas@fit.edu., Guruge C; Department of Chemistry and Chemical Engineering, Florida Institute of Technology, Melbourne, Florida 32901, USA. nesnas@fit.edu., Pabarue AB; Department of Chemistry and Chemical Engineering, Florida Institute of Technology, Melbourne, Florida 32901, USA. nesnas@fit.edu., Harris E; Department of Chemistry and Chemical Engineering, Florida Institute of Technology, Melbourne, Florida 32901, USA. nesnas@fit.edu., Peverati R; Department of Chemistry and Chemical Engineering, Florida Institute of Technology, Melbourne, Florida 32901, USA. nesnas@fit.edu., Nesnas N; Department of Chemistry and Chemical Engineering, Florida Institute of Technology, Melbourne, Florida 32901, USA. nesnas@fit.edu. |
| Abstrakt: |
Calcium ion (Ca 2+ ) control is an essential tool in neuronal research. Herein, we report three thiocoumarin-based, visible light-activated Ca 2+ chelators with quantum yields of 0.39, 0.52, and 0.83. The chelators demonstrated an over 10 5 -fold increase in Ca 2+ binding affinity upon irradiation. These chelators are efficiently triggered by biologically safer wavelengths, rendering them excellent candidates for use in neurological research and medicine. |
