Magnesium, selenium and zinc deficiency compromises antioxidant defense in women with obesity.

Autor: de Oliveira ARS; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil. ana.raquel@ufpi.edu.br., Cruz KJC; Departament of Nutrition, Campus Senator Helvídio Nunes de Barros, Federal University of Piauí, Picos, Piauí, Brazil., Morais JBS; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil., Dos Santos LR; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil., de Sousa Melo SR; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil., Fontenelle LC; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil., Severo JS; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil., Beserra JB; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil., de Sousa TGV; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil., de Freitas ST; Dean of Planning and Institucional Development, Federal University of Pará, Belém, Pará, Brazil., de Oliveira EHS; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil., Maia CSC; Department of Nutrition, State University of Ceará, Fortaleza, Ceará, Brazil., de Matos Neto EM; Department of Physical Education, Federal University of Piauí, Teresina, Piauí, Brazil., de Oliveira FE; DexLab Diagnostic Medicine Integrated Center, Teresina, Piauí, Brazil., Henriques GS; Department of Nursing, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Marreiro DDN; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil.
Jazyk: angličtina
Zdroj: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine [Biometals] 2024 Aug 19. Date of Electronic Publication: 2024 Aug 19.
DOI: 10.1007/s10534-024-00625-x
Abstrakt: Studies have shown that deficiencies in magnesium, selenium, and zinc in individuals with obesity compromise the endogenous antioxidant defense system. This study aimed to evaluate the impact of mineral deficiency on enzymatic antioxidant defense in women with obesity. The study involved 63 women with obesity (BMI ≥ 35 kg/m 2 ) and 77 eutrophic women (BMI between 18.5 and 24.9 kg/m 2 ). Variables such as fasting glucose, glycated hemoglobin, fasting insulin, and serum lipids were analyzed. Insulin resistance was measured using the homeostasis assessment model (HOMA-IR) and beta cell function using the homeostasis assessment model (HOMA-β). Dietary intake of energy, macronutrients (including magnesium, zinc, and selenium), and plasma, erythrocyte, and urinary concentrations of these minerals were measured and analyzed. Serum cortisol, plasma leptin, plasma thiobarbituric acid reactive substances, and the activity of erythrocyte superoxide dismutase (SOD), erythrocyte glutathione peroxidase (GPX), and erythrocyte catalase were also analyzed. Women with obesity had reduced plasma and erythrocyte concentrations and greater urinary excretion of all minerals compared to normal weight women (p < 0.05). There was a positive association between erythrocyte concentrations of zinc and selenium and the activity of the GPX and SOD enzymes in erythrocytes in women with obesity (p < 0.05), in addition to a positive association between serum insulin and the enzyme GPX, which is dependent on dietary selenium (p < 0.05). Individuals with obesity are deficient in magnesium, selenium, and zinc, which appears to impair the antioxidant defense system and contribute to important metabolic disorders such as oxidative stress in these patients.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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