Sensitivity of classification criteria from time of diagnosis in an incident systemic lupus erythematosus cohort: a population-based study from Norway.

Autor:	Haukeland H; Department of Rheumatology, Martina Hansens Hospital, Gjettum, Norway hildehaukeland1@gmail.com.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Moe SR; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Rheumatology, Oslo University Hospital, Oslo, Norway., Brunborg C; Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway., Botea A; Department of Rheumatology, Betanien Hospital, Skien, Norway., Damjanic N; Department of Rheumatology, Østfold Hospital Trust, Grålum, Norway., Wivestad GÅ; Division of Rheumatology, Department of Medicine, Hospital of Southern Norway Trust, Kristiansand, Norway., Øvreås HK; Department of Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway., Bøe TB; Department of Internal Medicine, Vestfold Hospital Trust, Tønsberg, Norway., Orre A; Department of Rheumatology, Vestre Viken Hospital Trust, Drammen, Norway., Torhild G; Department of Rheumatology, Oslo University Hospital, Oslo, Norway., Sanner H; Department of Rheumatology, Oslo University Hospital, Oslo, Norway.; Department of Health Sciences, Oslo New University College, Oslo, Norway., Lerang K; Department of Rheumatology, Oslo University Hospital, Oslo, Norway., Molberg Ø; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Rheumatology, Oslo University Hospital, Oslo, Norway.
Jazyk:	angličtina
Zdroj:	RMD open [RMD Open] 2024 Aug 19; Vol. 10 (3). Date of Electronic Publication: 2024 Aug 19.
DOI:	10.1136/rmdopen-2024-004395
Abstrakt:	Objectives: To compare the sensitivity of 2019 European Alliance of Associations for Rheumatology/American College of Rheumatology (EULAR/ACR) classification criteria against 1997 ACR criteria for systemic lupus erythematosus (SLE), for incident SLE cases in the presumably complete population-based Nor-SLE cohort from Southeast Norway (2.9 million inhabitants). Methods: All cases International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) coded as SLE during 2000-2017 were individually reviewed. Those with a confirmed SLE diagnosis by expert clinical assessment were included in the Nor-SLE cohort. Core clinical data were recorded, and the cases were classified according to 2019 EULAR/ACR and 1997 ACR criteria. Juvenile SLE was defined as <16 years at diagnosis and adult SLE was defined as ≥16 years at diagnosis. Results: We included 737 incident SLE cases (701 adults, 36 juveniles). At diagnosis, 2019 EULAR/ACR criteria were more sensitive than 1997 ACR criteria for adults (91.6% vs 77.3%; p<0.001), but not for juveniles (97.2% vs 88.9%). The 2019 EULAR/ACR counts at diagnosis differed by age group and ethnicity, being higher in young cases and those originating from Asia. From time of diagnosis to study end the fulfilment rate of 2019 EULAR/ACR criteria for the adult cohort increased from 92.5% and 86.5% to 94.6% and 91.0%, respectively, for females and males (mean disease duration of 7.5 years). Conclusion: Showing 92% criteria fulfilment already at time of SLE diagnosis by 2019 EULAR/ACR criteria versus 77% by 1997 ACR criteria, the results from this population-based study suggest that the 2019 EULAR/ACR criteria will achieve its goal of capturing more early-SLE cases for clinical trials. Competing Interests: Competing interests: KL has been engaged by AstraZeneca, Novartis and GSK. SRM has been engaged AstraZeneca and HH by UCB. The other authors have no conflicts of interest. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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