Protein-losing enteropathy as a result of colon polyposis and colon cancer: a multidisciplinary approach to diagnosis and treatment.
| Autor: | Kuipers H; Department of Gastroenterology and Hepatology, Isala Hospital, Zwolle, Netherlands h.kuipers@isala.nl., van Westreenen HL; Department of Surgery, Isala Hospital, Zwolle, Netherlands., Moll FCP; Department of Pathology, Isala Hospital, Zwolle, Netherlands., de Vos Tot Nederveen Cappel WH; Department of Gastroenterology and Hepatology, Isala Hospital, Zwolle, Netherlands. |
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| Jazyk: | angličtina |
| Zdroj: | BMJ case reports [BMJ Case Rep] 2024 Aug 19; Vol. 17 (8). Date of Electronic Publication: 2024 Aug 19. |
| DOI: | 10.1136/bcr-2024-261081 |
| Abstrakt: | A man in his 60s presented to our emergency department with severe peripheral pitting oedema, weight gain, dyspnoea and diarrhoea. Blood tests showed a hypoalbuminaemia of 15 g/L. A suspicion of protein-losing enteropathy arose after the exclusion of albuminuria, cardiac failure, protein deficiency and liver cirrhosis. An abdominal CT scan revealed a wall thickening of the colon, and a subsequent colonoscopy identified multiple large obstructive polyps in the ascending colon. The patient underwent a right hemicolectomy which revealed the presence of tubulovillous polyps and a pT2N0 colon carcinoma. Following surgery, the patient experienced clinical improvement with normalisation of serum albumin and resolution of the oedema.Protein-losing enteropathy should be considered an underlying syndrome in patients with peripheral oedema and hypoalbuminaemia in the absence of cardiac failure, proteinuria, malnutrition and hepatic disease. This diagnostic process requires a multidisciplinary approach. For adequate treatment, the primary cause of protein-losing enteropathy needs to be investigated. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.) |
| Databáze: | MEDLINE |
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