FAM210A: An emerging regulator of mitochondrial homeostasis.

Autor: Wang Y; Department of Animal Sciences, University of Florida, Gainesville, Florida, USA., Yue F; Department of Animal Sciences, University of Florida, Gainesville, Florida, USA.; Myology Institute, University of Florida, Gainesville, Florida, USA.
Jazyk: angličtina
Zdroj: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2024 Oct; Vol. 46 (10), pp. e2400090. Date of Electronic Publication: 2024 Aug 19.
DOI: 10.1002/bies.202400090
Abstrakt: Mitochondrial homeostasis serves as a cornerstone of cellular function, orchestrating a delicate balance between energy production, redox status, and cellular signaling transduction. This equilibrium involves a myriad of interconnected processes, including mitochondrial dynamics, quality control mechanisms, and biogenesis and degradation. Perturbations in mitochondrial homeostasis have been implicated in a wide range of diseases, including neurodegenerative diseases, metabolic syndromes, and aging-related disorders. In the past decades, the discovery of numerous mitochondrial proteins and signaling has led to a more complete understanding of the intricate mechanisms underlying mitochondrial homeostasis. Recent studies have revealed that Family with sequence similarity 210 member A (FAM210A) is a novel nuclear-encoded mitochondrial protein involved in multiple aspects of mitochondrial homeostasis, including mitochondrial quality control, dynamics, cristae remodeling, metabolism, and proteostasis. Here, we review the function and physiological role of FAM210A in cellular and organismal health. This review discusses how FAM210A acts as a regulator on mitochondrial inner membrane to coordinate mitochondrial dynamics and metabolism.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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