How auditory neurons count temporal intervals and decode information.

Autor:	Alluri RK; School of Biological Sciences, University of Utah, Salt Lake City, UT 84112., Rose GJ; School of Biological Sciences, University of Utah, Salt Lake City, UT 84112., McDowell J; Department of Psychology, University of California, Los Angeles, CA 90095., Mukhopadhyay A; School of Biological Sciences, University of Utah, Salt Lake City, UT 84112., Leary CJ; Department of Biology, University of Mississippi, Oxford, MS 38677., Graham JA; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755., Vasquez-Opazo GA; Department of Neurobiology, School of Medicine, University of Utah, Salt Lake City, UT 84112.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Aug 27; Vol. 121 (35), pp. e2404157121. Date of Electronic Publication: 2024 Aug 19.
DOI:	10.1073/pnas.2404157121
Abstrakt:	The numerical sense of animals includes identifying the numerosity of a sequence of events that occur with specific intervals, e.g., notes in a call or bar of music. Across nervous systems, the temporal patterning of spikes can code these events, but how this information is decoded (counted) remains elusive. In the anuran auditory system, temporal information of this type is decoded in the midbrain, where "interval-counting" neurons spike only after at least a threshold number of sound pulses have occurred with specific timing. We show that this decoding process, i.e., interval counting, arises from integrating phasic, onset-type and offset inhibition with excitation that augments across successive intervals, possibly due to a progressive decrease in "shunting" effects of inhibition. Because these physiological properties are ubiquitous within and across central nervous systems, interval counting may be a general mechanism for decoding diverse information coded/encoded in temporal patterns of spikes, including "bursts," and estimating elapsed time. Competing Interests: Competing interests statement:The authors declare no competing interest.
Databáze:	MEDLINE
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