Evidence of association between higher cardiorespiratory fitness and higher cerebral myelination in aging.

Autor: Faulkner ME; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224., Gong Z; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224., Bilgel M; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD 21224., Laporte JP; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224., Guo A; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224., Bae J; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224., Palchamy E; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224., Kaileh M; Clinical Research Core, National Institute on Aging, NIH, Baltimore, MD 21224., Bergeron CM; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224., Bergeron J; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224., Church S; Clinical Research Core, National Institute on Aging, NIH, Baltimore, MD 21224., D'Agostino J; Clinical Research Core, National Institute on Aging, NIH, Baltimore, MD 21224., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224., Bouhrara M; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224.
Jazyk: angličtina
Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Aug 27; Vol. 121 (35), pp. e2402813121. Date of Electronic Publication: 2024 Aug 19.
DOI: 10.1073/pnas.2402813121
Abstrakt: Emerging evidence suggests that altered myelination is an important pathophysiologic correlate of several neurodegenerative diseases, including Alzheimer and Parkinson's diseases. Thus, improving myelin integrity may be an effective intervention to prevent and treat age-associated neurodegenerative pathologies. It has been suggested that cardiorespiratory fitness (CRF) may preserve and enhance cerebral myelination throughout the adult lifespan, but this hypothesis has not been fully tested. Among cognitively normal participants from two well-characterized studies spanning a wide age range, we assessed CRF operationalized as the maximum rate of oxygen consumption (VO 2 max) and myelin content defined by myelin water fraction (MWF) estimated through our advanced multicomponent relaxometry MRI method. We found significant positive correlations between VO 2 max and MWF across several white matter regions. Interestingly, the effect size of this association was higher in brain regions susceptible to early degeneration, including the frontal lobes and major white matter fiber tracts. Further, the interaction between age and VO 2 max exhibited i) a steeper positive slope in the older age group, suggesting that the association of VO 2 max with MWF is stronger at middle and older ages and ii) a steeper negative slope in the lower VO 2 max group, indicating that lower VO 2 max levels are associated with lower myelination with increasing age. Finally, the nonlinear pattern of myelin maturation and decline is VO 2 max-dependent with the higher VO 2 max group reaching the MWF peak at later ages. This study provides evidence of an interconnection between CRF and cerebral myelination and suggests therapeutic strategies for promoting brain health and attenuating white matter degeneration.
Competing Interests: Competing interests statement:The authors declare no competing interest.
Databáze: MEDLINE
Externí odkaz: