A Comprehensive Compilation of Data on the Relationship Between Surfactant Protein-B (SFTPB) Polymorphisms and Susceptibility to Neonatal Respiratory Distress Syndrome.

Autor:	Golshan-Tafti M; Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran., Bahrami R; Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Dastgheib SA; Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Lookzadeh MH; Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Mirjalili SR; Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Yeganegi M; Department of Obstetrics and Gynecology, Iranshahr University of Medical Sciences, Iranshahr, Iran., Marzbanrad Z; Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran., Aghasipour M; Department of Cancer Biology, College of Medicine, University of Cincinnati, OH, USA., Shahbazi A; Student Research Committee, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran., Masoudi A; General Practitioner, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Noorishadkam M; Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Neamatzadeh H; Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Jazyk:	angličtina
Zdroj:	Fetal and pediatric pathology [Fetal Pediatr Pathol] 2024 Sep-Oct; Vol. 43 (5), pp. 399-418. Date of Electronic Publication: 2024 Aug 19.
DOI:	10.1080/15513815.2024.2390932
Abstrakt:	Background: This study aims to explore the association between variations in the Surfactant Protein-B (SFTPB) gene and the risk of neonatal respiratory distress syndrome (NRDS). Methods: A comprehensive literature search was conducted across PubMed, Scopus, EMBASE, and CNKI databases up to February 10, 2024, to identify pertinent studies. Results: A total of seventeen studies examining the +1580 C/T polymorphism (2,058 cases and 2,596 controls) and five studies investigating the -18 A/C polymorphism (680 cases and 739 controls) were included in the analysis. The pooled data indicated that the +1580 C/T polymorphism confers a protective effect against NRDS in various populations and ethnic groups. Conversely, the -18 A/C polymorphism did not demonstrate a significant association either globally or among Asian neonates. Conclusions: The +1580 C/T variant appears to be protective against NRDS, whereas the -18 A/C polymorphism shows minimal impact on the disease's progression.
Databáze:	MEDLINE
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