miRNA, New Perspective to World of Intestinal Protozoa and Toxoplasma.

Autor: Hamidi F; Department of Laboratory Sciences and Microbiology, Faculty of Medical Sciences, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran., Taghipour N; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. nilitaghipour@gmail.com.
Jazyk: angličtina
Zdroj: Acta parasitologica [Acta Parasitol] 2024 Sep; Vol. 69 (3), pp. 1690-1703. Date of Electronic Publication: 2024 Aug 19.
DOI: 10.1007/s11686-024-00888-x
Abstrakt: Background: miRNAs are known as non-coding RNAs that can regulate gene expression. They are reported in many microorganisms and their host cells. Parasite infection can change or shift host miRNAs expression, which can aim at both parasite eradication and infection.
Purpose: This study dealt with examination of miRNA expressed in intestinal protozoan, coccidia , as well as profile changes in host cell miRNA after parasitic infection and their role in protozoan clearance/ survival.
Methods: The authors searched ISI Web of Sciences, Pubmed, Scholar, Scopus, another databases and articles published up to 2024 were included. The keywords of miRNA, intestinal protozoa, toxoplasma and some words associated with topics were used in this search.
Results: Transfection of miRNA mimics or inhibitors can control parasitic diseases, and be introduced as a new therapeutic option in parasitology.
Conclusion: This review can be used to provide up-to date knowledge for future research on these issues.
(© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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