Yinxie I Formula attenuates imiquimod-induced psoriasis-like skin inflammation via IL-23/IL-17 axis.

Autor: Yanping H; Department of Dermatology, General Hospital of Ningxia Medical University, No. 804 Shengli Street, Yinchuan, 750004, Ningxia Hui Autonomous Region, PR China., Ting G; Department of Dermatology, General Hospital of Ningxia Medical University, No. 804 Shengli Street, Yinchuan, 750004, Ningxia Hui Autonomous Region, PR China., Xinzhu Z; Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, PR China., Yaya L; Department of Dermatology, General Hospital of Ningxia Medical University, No. 804 Shengli Street, Yinchuan, 750004, Ningxia Hui Autonomous Region, PR China., Yuna Z; Department of Dermatology, General Hospital of Ningxia Medical University, No. 804 Shengli Street, Yinchuan, 750004, Ningxia Hui Autonomous Region, PR China., Qing L; Department of Dermatology, General Hospital of Ningxia Medical University, No. 804 Shengli Street, Yinchuan, 750004, Ningxia Hui Autonomous Region, PR China., Xueli M; Department of Dermatology, General Hospital of Ningxia Medical University, No. 804 Shengli Street, Yinchuan, 750004, Ningxia Hui Autonomous Region, PR China., Jing C; Department of Dermatology, General Hospital of Ningxia Medical University, No. 804 Shengli Street, Yinchuan, 750004, Ningxia Hui Autonomous Region, PR China. cjfsyy@163.com.
Jazyk: angličtina
Zdroj: Archives of dermatological research [Arch Dermatol Res] 2024 Aug 19; Vol. 316 (8), pp. 540. Date of Electronic Publication: 2024 Aug 19.
DOI: 10.1007/s00403-024-03288-3
Abstrakt: Psoriasis is considered a chronic inflammatory skin disorder characterized by keratinocytes hyperproliferation. The IL-23/IL-17 immune pathway has been substantiated in numerous studies to be closely associated with psoriasis progression. Yinxie I Formula is a traditional Chinese medicine made from 9 herbal medicines, which has excellent clinical efficacy in psoriasis. However, to date, the mechanism of action of Yinxie I Formula against psoriasis remains unknown. In this perspective, we discuss the efficacy of Yinxie I Formula in mice with imiquimod (IMQ) induced psoriasis. Yinxie I Formula significantly reduced the area of skin lesions and the inflammatory response in mice with psoriasis. Furthermore, Yinxie I Formula alleviated the expression levels of inflammation-related genes IL-6, IL-17 A, IL-22, IL-23, TNF-α and IL-23, IL-18, IL-6 and IL-1β-related proteins and alleviated the abnormal surge of dendritic cells, macrophages and T cells in the skin and spleen. Meanwhile we found that Yinxie I Formula reduced the release of NO, TNF-α, IL-1β and IL-23 in lipopolysaccharide-induced mouse macrophage RAW264.7 cell line. The results suggest that the therapeutic mechanism of Yinxie I Formula may also be correlated with the STAT signaling pathway. We further analyzed the active ingredient of Yinxie I Formula, Buddleoside, which may be the main substance that exerts the therapeutic effect. In conclusion, we have investigated that Yinxie I Formula attenuates the IMQ-induced inflammatory response in psoriasis by inhibiting the IL-23/IL-17 axis, which lays the foundation for the antipsoriasis mechanism and provides a theoretical basis for the clinical promotion of Yinxie I Formula.
(© 2024. The Author(s).)
Databáze: MEDLINE
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