Sex differences in prevalence and characteristics of imaging-detected atherosclerosis: a population-based study.

Autor:	Swahn E; Department of Cardiology, Linköping University, SE-58185 Linköping, Sweden.; Department of Health, Medicine and Caring Sciences, Linköping University, SE-58183 Linköping, Sweden., Sederholm Lawesson S; Department of Cardiology, Linköping University, SE-58185 Linköping, Sweden.; Department of Health, Medicine and Caring Sciences, Linköping University, SE-58183 Linköping, Sweden., Alfredsson J; Department of Cardiology, Linköping University, SE-58185 Linköping, Sweden.; Department of Health, Medicine and Caring Sciences, Linköping University, SE-58183 Linköping, Sweden., Fredrikson M; Forum Östergötland, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.; Inflammation and Infection, Department of Experimental and Clinical Medicine, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden., Angerås O; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Duvernoy O; Department of Surgical Sciences, Section of Radiology, Uppsala University, Uppsala, Sweden., Engström G; Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden., Eriksson MJ; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Department of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden., Fagman E; Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Johansson B; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Johnson L; Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden., Johnston N; Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden., Ljungberg J; Department of Public Health and Clinical Medicine, Medicine and Heart Centre, Umeå University, Umeå, Sweden., Mannila M; Department of Cardiology and Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden., Nordendahl M; Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, Sweden., Oldgren J; Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden., Omerovic E; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Ostenfeld E; Department of Clinical Sciences Lund, Clinical Physiology, Lund University, Skåne University Hospital, Lund, Sweden., Persson M; Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden., Rosengren A; Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Medicine Geriatrics and Emergency Medicine, Sahlgrenska University Hospital Östra Hospital, Gothenburg, Sweden., Skoglund Larsson L; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Sundström J; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.; The George Institute for Global Health, University of New South Wales, Sydney, Australia., Söderberg M; Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Östgren CJ; CMIV Centre of Medical Image Science and Visualization, Linköping University, Linköping, Sweden.; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping  Sweden., Leander K; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Jernberg T; Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden.
Jazyk:	angličtina
Zdroj:	European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2024 Nov 27; Vol. 25 (12), pp. 1663-1672.
DOI:	10.1093/ehjci/jeae217
Abstrakt:	Aims: Men are more likely to suffer a myocardial infarction than women, but population-based studies on sex differences in imaging-detected atherosclerosis are lacking. The aims were to assess sex differences in the prevalence of imaging-detected coronary and carotid atherosclerosis, as well as multivariable adjusted associations between sex and atherosclerosis. Methods and Results: Participants aged 50-65, recruited from the general population to the Swedish Cardiopulmonary bioImage Study (SCAPIS), were included in this population-based cross-sectional study. Comprehensive diagnostics, including coronary computed tomography angiography and carotid ultrasound, were performed. The image findings were any coronary atherosclerosis, coronary stenosis ≥ 50%, segment involvement score (SIS) ≥ 4, coronary artery calcium score (CACS) > 100, and any ultrasound-detected carotid plaque. In 25 580 participants (50% women), men had more hypertension (20.3% vs. 17.0%), hyperlipidaemia (9.0% vs. 5.5%), and diabetes (8.5% vs. 4.7%). The prevalence was 56.2% vs. 29.5% for any coronary atherosclerosis (P < 0.01), 9.0% vs. 2.3% for coronary stenosis ≥ 50% (P < 0.01), 20.2% vs. 5.3% for SIS ≥ 4 (P < 0.01), 18.2% vs. 5.6% for CACS > 100 (P < 0.01), and 60.9% vs. 48.7% for carotid plaque (P < 0.01), in men vs. women, respectively. Multivariable adjustment only marginally changed these associations: odds ratios (ORs) (95% confidence interval): 2.75 (2.53-2.99) for coronary atherosclerosis, 2.88 (2.40-3.45) for coronary stenosis ≥ 50%, 3.99 (3.50-4.55) for SIS ≥ 4, 3.29 (2.88-3.75) for CACS > 100, and 1.57 (1.45-1.70) for carotid plaque. Conclusion: Men had higher prevalence of imaging-detected carotid and coronary atherosclerosis with prevalence in women aged 65 corresponding to men 11-13 years younger. The associations remained after extensive multivariable adjustment. Competing Interests: Conflict of interest: L.J. receives consulting fees from MEDICALgorithmics. S.S.L. has received speaker fees from Pfizer and Bayer. J.S. is a shareholder in Anagram kommunikation AB and Symptoms Europe AB, unrelated to the present study. The remaining authors have nothing to disclose. (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
Databáze:	MEDLINE
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