A Protocol to Determine Circadian Phase by At-Home Salivary Dim Light Melatonin Onset Assessment.

Autor: Murray JM; School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia.; Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia., Stone JE; School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia.; Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia., Abbott SM; Department of Neurology, Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Bjorvatn B; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.; Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital, Bergen, Norway., Burgess HJ; Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA., Cajochen C; Centre for Chronobiology, Psychiatric Hospital of the University of Basel (UPK), Basel, Switzerland.; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland., Dekker JJ; Department of Data Science and AI, Monash University, Melbourne, Victoria, Australia., Duffy JF; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA., Epstein LJ; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA., Garbazza C; Centre for Chronobiology, Psychiatric Hospital of the University of Basel (UPK), Basel, Switzerland.; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland.; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA., Harsh J; Sleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., Klerman EB; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA., Lane JM; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Lockley SW; School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia.; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK., Pavlova MK; Department of Neurology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA., Quan SF; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA., Reid KJ; Department of Neurology, Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Scheer FAJL; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts, USA., Sletten TL; School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia.; Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia., Wright KP Jr; Sleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., Zee PC; Department of Neurology, Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Phillips AJK; Flinders Health and Medical Research Institute (Sleep Health), Flinders University, Bedford Park, South Australia, Australia., Czeisler CA; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA., Rajaratnam SMW; School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia.; Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia.; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Jazyk: angličtina
Zdroj: Journal of pineal research [J Pineal Res] 2024 Aug; Vol. 76 (5), pp. e12994.
DOI: 10.1111/jpi.12994
Abstrakt: Internal circadian phase assessment is increasingly acknowledged as a critical clinical tool for the diagnosis, monitoring, and treatment of circadian rhythm sleep-wake disorders and for investigating circadian timing in other medical disorders. The widespread use of in-laboratory circadian phase assessments in routine practice has been limited, most likely because circadian phase assessment is not required by formal diagnostic nosologies, and is not generally covered by insurance. At-home assessment of salivary dim light melatonin onset (DLMO, a validated circadian phase marker) is an increasingly accepted approach to assess circadian phase. This approach may help meet the increased demand for assessments and has the advantages of lower cost and greater patient convenience. We reviewed the literature describing at-home salivary DLMO assessment methods and identified factors deemed to be important to successful implementation. Here, we provide specific protocol recommendations for conducting at-home salivary DLMO assessments to facilitate a standardized approach for clinical and research purposes. Key factors include control of lighting, sampling rate, and timing, and measures of patient compliance. We include findings from implementation of an optimization algorithm to determine the most efficient number and timing of samples in patients with Delayed Sleep-Wake Phase Disorder. We also provide recommendations for assay methods and interpretation. Providing definitive criteria for each factor, along with detailed instructions for protocol implementation, will enable more widespread adoption of at-home circadian phase assessments as a standardized clinical diagnostic, monitoring, and treatment tool.
(© 2024 The Author(s). Journal of Pineal Research published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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