[Pharmacovigilance of vaccines against COVID-19 in community pharmacies. Results after the second dose and comparison between both].

Autor: Mera-Gallego R; Farmacéutica comunitaria en Vigo España.; Grupo Berbés de Investigación y Docencia Grupo Berbés de Investigación y Docencia España., León-Rodríguez L; Doctora en Farmacia. Farmacéutica comunitaria en Ourense. España.; Grupo Berbés de Investigación y Docencia Grupo Berbés de Investigación y Docencia España., Barreiro Juncal M; Farmacéutica comunitaria en Vigo España.; Grupo Berbés de Investigación y Docencia Grupo Berbés de Investigación y Docencia España., Pérez Molina L; Farmacéutica comunitaria en Vigo España.; Grupo Berbés de Investigación y Docencia Grupo Berbés de Investigación y Docencia España., Guisado Barral B; Farmacéutica comunitaria en Crecente (Pontevedra).C España.; Grupo Berbés de Investigación y Docencia Grupo Berbés de Investigación y Docencia España., Busto Domínguez I; Departamento técnico del Colegio Oficial de Farmacéuticos de Pontevedra Colegio Oficial de Farmacéuticos de Pontevedra España.; Grupo Berbés de Investigación y Docencia Grupo Berbés de Investigación y Docencia España., Andrés-Rodríguez NF; Doctor en Farmacia Farmacia España.; Grupo Berbés de Investigación y Docencia Grupo Berbés de Investigación y Docencia España., Fornos-Pérez JA; Doctor en Farmacia. Farmacéutico comunitario en Cangas do Morrazo (Pontevedra) España.; Grupo Berbés de Investigación y Docencia Grupo Berbés de Investigación y Docencia España.
Jazyk: Spanish; Castilian
Zdroj: Farmaceuticos comunitarios [Farm Comunitarios] 2023 Jun 01; Vol. 15 (3), pp. 5-16. Date of Electronic Publication: 2023 Jun 01 (Print Publication: 2023).
DOI: 10.33620/FC.2173-9218.(2023).21
Abstrakt: Aim: Detection and tracing of suspicious adverse reactions (ARs) in community pharmacies after the second of COVID-19 vaccine dose. Comparison between doses.
Methods: Design: prospective observational study.
Subjects: Vaccinated against COVID-19, of legal age, who consent to participate.
Variables: Number and percentage of participants with ARs. Number, type and frequency of ARs. Impact on their daily life. Relations between variables.Approved by the Galician Ethical Committee of Research with medicines.
Results: 693 participants with the 2nd dose, 63.6% women. Age 56.8 years. 312 (45.0%) vaccinated, 49.4% women and 37.3% men (p<0.0001), reported at least one AR: 43.9% with Comirnaty®, 37.7% with Vaxzevria®, 63.0% with Spikevax®.There were 972 ARs, 75.2% in women and 24.8% in men (p<0.0001). Mean 1.4/vaccinated (maximum 11). The most prevalent AR: pain at injection site 197 (28.4%), tiredness/fatigue 141 (20.3%), myalgia 112 (16.2%), headache 95 (13.7%), fever 84 (12.1%).51 participants with ARs needed professional help: 10 from the doctor, 6 in the emergency room, 3 in hospitals (1 referral), 33 in the pharmacy. 70 (15.1%) were prevented from their daily activity. 201 Ars from vaccinated persons were reported.Number of people vaccinated with ARs and the number of ARs were less with the 2nd dose (p<0.05).Inverse relationship (p<0.05) between "age" and "number of vaccinated with ARs", "need for professional care" and "prevented daily activity".
Conclusions: The number of vaccinated participants with ARs and their number was also high with the second dose, although lower than with the first. Women and younger people are predictive of increased risk of AR after vaccination against COVID-19.
(Copyright SEFAC. Sociedad Española de Farmacia Clínica, Familiar y Comunitaria. This article is available from url https://www.farmaceuticoscomunitarios.org/.)
Databáze: MEDLINE