Unveiling the nephrotoxic profile of BCR-ABL tyrosine kinase inhibitors: A real-world experience in Africa.

Autor: Ayalew ZS; Department of Internal Medicine Addis Ababa University Addis Ababa Ethiopia., Azibte GT; Department of Internal Medicine Addis Ababa University Addis Ababa Ethiopia., Tadesse F; Department of Internal Medicine, Division of Hematology Addis Ababa University Addis Ababa Ethiopia., Legesse BA; Department of Internal Medicine Addis Ababa University Addis Ababa Ethiopia., Kiflu ZG; Department of Internal Medicine Addis Ababa University Addis Ababa Ethiopia., Weldeamanuel MT; Department of Internal Medicine Addis Ababa University Addis Ababa Ethiopia., Tsige KA; Department of Clinical Oncology Addis Ababa University Addis Ababa Ethiopia., Molla BA; Department of Internal Medicine Addis Ababa University Addis Ababa Ethiopia., Ejigu AM; Department of Internal Medicine, Division of Nephrology Addis Ababa University Addis Ababa Ethiopia.
Jazyk: angličtina
Zdroj: EJHaem [EJHaem] 2024 Jul 31; Vol. 5 (4), pp. 749-756. Date of Electronic Publication: 2024 Jul 31 (Print Publication: 2024).
DOI: 10.1002/jha2.988
Abstrakt: Introduction: The efficacy of BCR-ABL tyrosine kinase inhibitors (TKIs) in treating chronic myelogenous leukemia and other malignancies is well-documented. However, concerns about potential nephrotoxicity have raised questions. This study, conducted at Tikur Anbesa Specialized Hospital (TASH) in Addis Ababa, Ethiopia, aimed to investigate the association between TKIs and renal toxicities.
Methods: A hospital-based cross-sectional design was used to enroll 260 TASH patients actively receiving BCR-ABL TKIs. Demographic information, diagnoses, treatment details, and laboratory test results were collected for each participant's Electronic Medical Record. The primary goal was to assess adverse renal events, a combination of events of a decrease in estimated glomerular filtration rate (eGFR) exceeding 30% from baseline, significant proteinuria, and a diagnosis of acute kidney injury (AKI) or chronic kidney disease (CKD). A logistic regression model was used to analyze the data and identify factors associated with developing adverse renal events.
Results: Our analysis revealed a statistically significant decrease in eGFR following treatment with TKIs. However, the observed rate of adverse renal events (13.1%) was lower than reported in some previous studies. Factors significantly associated with adverse renal events included longer TKI duration, male sex (protective), hypertension, HIV infection, and achieving complete molecular remission and/or a complete hematologic response. No significant associations were found with diabetes mellitus, age, angiotensin-converting enzyme inhibitors use, or baseline creatinine level.
Conclusions: While this study found that BCR-ABL TKIs can lead to a decline in eGFR, AKI, and CKD, it also demonstrated that they were relatively safer in our study population.
Competing Interests: The authors declare no conflict of interest.
(© 2024 The Author(s). eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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