Carnitine consumption and effect of oral supplementation in human pulmonary arterial hypertension: A pilot study.

Autor: Brittain EL; Division of Cardiovascular Medicine Vanderbilt University Medical Center Nashville Tennessee USA., Lindsey A; Division of Allergy, Pulmonary and Critical Care Medicine Vanderbilt University Medical Center Nashville Tennessee USA., Burke K; Division of Allergy, Pulmonary and Critical Care Medicine Vanderbilt University Medical Center Nashville Tennessee USA., Agrawal V; Division of Cardiovascular Medicine Vanderbilt University Medical Center Nashville Tennessee USA., Robbins I; Division of Allergy, Pulmonary and Critical Care Medicine Vanderbilt University Medical Center Nashville Tennessee USA., Pugh M; Division of Allergy, Pulmonary and Critical Care Medicine Vanderbilt University Medical Center Nashville Tennessee USA., Calcutt MW; Department of Biochemistry Vanderbilt University Medical Center Nashville Tennessee USA., Mallugari R; Division of Cardiovascular Medicine Vanderbilt University Medical Center Nashville Tennessee USA., West J; Division of Allergy, Pulmonary and Critical Care Medicine Vanderbilt University Medical Center Nashville Tennessee USA., Nian H; Department of Biostatistics Vanderbilt University Medical Center Nashville Tennessee USA., Hemnes AR; Division of Allergy, Pulmonary and Critical Care Medicine Vanderbilt University Medical Center Nashville Tennessee USA.
Jazyk: angličtina
Zdroj: Pulmonary circulation [Pulm Circ] 2024 Aug 15; Vol. 14 (3), pp. e12425. Date of Electronic Publication: 2024 Aug 15 (Print Publication: 2024).
DOI: 10.1002/pul2.12425
Abstrakt: Carnitine is required to transport fatty acid across the mitochondrial membrane to undergo beta oxidation. In addition to disorders of fatty acid metabolism, a relative carnitine deficiency has been reported in pulmonary arterial hypertension (PAH). Here we performed an observational study in which food and supplement consumption were collected in an observation period followed by open label administration of a carnitine supplement to determine feasibility of increasing plasma carnitine levels in humans PAH. We confirmed that relative carnitine deficiency in PAH is not due to reduced dietary consumption and that plasma levels of carnitine can be increased in PAH patients with supplementation that is well tolerated.
Competing Interests: The authors report no relevant conflicts of interest.
(© 2024 The Author(s). Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.)
Databáze: MEDLINE
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