Cytoprotective Effect of Gallic Acid against Injuries Promoted by Therapeutic Ionizing Radiation in Preosteoblast Cells.

Autor:	Leite RS; Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros, Minas Gerais, Brazil., da Rocha RG; Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros, Minas Gerais, Brazil., Lima Tabosa AT; Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros, Minas Gerais, Brazil., Batista Gomes ES; Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros, Minas Gerais, Brazil., Santiago L; Oncological Radiology Center, Hospital Dilson Godinho, Montes Claros, Minas Gerais, Brazil., Rodrigues DC; Department of Dentistry, Universidade Estadual de Montes Claros, Minas Gerais, Brazil., Sousa Santos SH; Institute of Agricultural Sciences, Food Engineering College, Universidade Federal de Minas Gerais, Montes Claros, Minas Gerais, Brazil., Sena Guimarães AL; Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros, Minas Gerais, Brazil.; Department of Dentistry, Universidade Estadual de Montes Claros, Minas Gerais, Brazil., Farias LC; Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros, Minas Gerais, Brazil.; Department of Dentistry, Universidade Estadual de Montes Claros, Minas Gerais, Brazil.
Jazyk:	angličtina
Zdroj:	International journal of molecular and cellular medicine [Int J Mol Cell Med] 2024; Vol. 13 (1), pp. 19-28.
DOI:	10.22088/IJMCM.BUMS.13.1.19
Abstrakt:	Gallic acid (GA) is a powerful antioxidant extracted from plants of the Brazilian Cerrado. Oxidative stress plays an important role in the occurrence of radiation-induced osteonecrosis in patients treated for head and neck cancer. There is a need to develop research aimed at developing complementary therapies to prevent or reverse bone damage. The aim of the present study was to investigate the effect of GA in preosteoblasts exposed to therapeutic ionizing radiation. MC3T3-E1 preosteoblast cells were treated with 10 µM GA and exposed to 6 Gy ionizing radiation. We performed in vitro assays of cell proliferation, oxidative stress analysis by detection of reactive oxygen species, and alkaline phosphatase assay. GA at lower concentrations was able to significantly increase proliferation and inhibit radiation-induced generation of reactive oxygen species in osteoblast precursor cells, despite ionizing radiation-induced injury. Furthermore, GA significantly increased alkaline phosphatase at a dose of 6 Gy. The findings suggested that GA could attenuate ionizing radiation-induced injuries in osteoblast precursor cells. Moreover, in vivo studies are needed to better investigate the role of GA in osteonecrosis, especially in cancer patients undergoing radiotherapy or taking antiresorptive drugs. (© The Author(s).)
Databáze:	MEDLINE
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