Exposure to Mycophenolic Acid and Its Clinical Response in an Indian Pediatric Population with Nephrotic Syndrome.
| Autor: | Deepthi RV; Department of Pediatric Nephrology, Christian Medical College, Vellore, Tamil Nadu, India., Arumadi M; Department of Pediatric Nephrology, Christian Medical College, Vellore, Tamil Nadu, India., Eriyat V; Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, Tamil Nadu, India., Mathew SK; Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, Tamil Nadu, India., Mathew BS; Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, Tamil Nadu, India., Agarwal I; Department of Pediatric Nephrology, Christian Medical College, Vellore, Tamil Nadu, India., Prabha R; Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, Tamil Nadu, India. |
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| Jazyk: | angličtina |
| Zdroj: | Indian journal of nephrology [Indian J Nephrol] 2024 Jul-Aug; Vol. 34 (4), pp. 323-327. Date of Electronic Publication: 2024 May 11. |
| DOI: | 10.25259/ijn_390_22 |
| Abstrakt: | Background: Children with nephrotic syndrome experience many side effects and frequent relapses when treated with steroids and other drugs. Mycophenolic acid (MPA) is one of the effective and least toxic drug for the treatment of nephrotic syndrome. This drug needs to be monitored for maximal efficacy and minimal toxicity. The therapeutic reference range for this drug is not established for the aforementioned patient population of Indian origin. Materials and Methods: In this observational study, children with nephrotic syndrome on mycophenolate mofetil were followed up for a minimum duration of three months. Following this, their clinical status (relapse/remission) was determined and the mycophenolate exposure was measured for over 12 hours. Results: A total of 34 participants were included, with 17 (50%) in relapse. Median MPA Area under the curve over 12 hours (AUC0-12h) (36.5 µg·h/ml) in the remission group differed significantly compared to that in the relapse group (17.2 µg·h/ml). Conclusion: Higher exposure to MPA AUC0-12h is associated with clinical remission of pediatric nephrotic syndrome. Competing Interests: There are no conflicts of interest. (© 2024 Indian Journal of Nephrology | Published by Scientific Scholar.) |
| Databáze: | MEDLINE |
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