Multivariate analyses and machine learning link sex and age with antibody responses to SARS-CoV-2 and vaccination.

Autor:	Cuperlovic-Culf M; Digital Technologies Research Centre, National Research Council of Canada, 1200 Montreal Road, Ottawa, ON K1A 0R6, Canada.; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Bennett SAL; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Galipeau Y; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., McCluskie PS; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Arnold C; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Bagheri S; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Coronavirus Variants Rapid Response Network (CoVaRR-Net), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada., Cooper CL; Coronavirus Variants Rapid Response Network (CoVaRR-Net), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Division of Infectious Diseases, Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Langlois MA; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Coronavirus Variants Rapid Response Network (CoVaRR-Net), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Fritz JH; Coronavirus Variants Rapid Response Network (CoVaRR-Net), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Department of Microbiology and Immunology, McGill University, Montréal, QC, Canada.; Program in Infectious Diseases and Immunology in Global Health, The Research Institute of the McGill University Health Centre (RI-MUHC), Montréal, QC, Canada.; Centre of Excellence in Translational Immunology (CETI), Montréal, QC, Canada.; McGill University Research Centre on Complex Traits (MRCCT), Montréal, QC, Canada., Piccirillo CA; Coronavirus Variants Rapid Response Network (CoVaRR-Net), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Department of Microbiology and Immunology, McGill University, Montréal, QC, Canada.; Program in Infectious Diseases and Immunology in Global Health, The Research Institute of the McGill University Health Centre (RI-MUHC), Montréal, QC, Canada.; Centre of Excellence in Translational Immunology (CETI), Montréal, QC, Canada.; McGill University Research Centre on Complex Traits (MRCCT), Montréal, QC, Canada., Crawley AM; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Coronavirus Variants Rapid Response Network (CoVaRR-Net), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2024 Jul 10; Vol. 27 (8), pp. 110484. Date of Electronic Publication: 2024 Jul 10 (Print Publication: 2024).
DOI:	10.1016/j.isci.2024.110484
Abstrakt:	Prevention of negative COVID-19 infection outcomes is associated with the quality of antibody responses, whose variance by age and sex is poorly understood. Network approaches identified sex and age effects in antibody responses and neutralization potential of de novo infection and vaccination throughout the COVID-19 pandemic. Neutralization values followed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific receptor binding immunoglobulin G (RIgG), spike immunoglobulin G (SIgG) and spike and receptor immunoglobulin G (S, and RIgA) levels based on COVID-19 status. Serum immunoglobulin A (IgA) antibody titers correlated with neutralization only in females 40-60 years old (y.o.). Network analysis found males could improve IgA responses after vaccination dose 2. Complex correlation analyses found vaccination induced less antibody isotype switching and neutralization in older persons, especially in females. Sex-dependent antibody and neutralization decayed the fastest in older males. Shown sex and age characterization can direct studies integrating cell-mediated responses to define yet elusive correlates of protection and inform age and sex precision-focused vaccine design. Competing Interests: The authors declare no competing interests. (© 2024 The Authors.)
Databáze:	MEDLINE
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