Mining human clinical waste as a rich source of stem cells for neural regeneration.

Autor:	Eivazi Zadeh Z; Department of Biomedical Engineering, University of Melbourne, Parkville, VIC 3010, Australia.; The Graeme Clark Institute, University of Melbourne, Melbourne, VIC, Australia., Nour S; Department of Biomedical Engineering, University of Melbourne, Parkville, VIC 3010, Australia.; The Graeme Clark Institute, University of Melbourne, Melbourne, VIC, Australia.; Polymer Science Group, Department of Chemical Engineering, University of Melbourne, Parkville, VIC 3010, Australia., Kianersi S; Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CÚRAM), Biomedical Sciences, University of Galway, Galway, Ireland., Jonidi Shariatzadeh F; Biomedical Engineering, Faculty of Engineering, University of Manitoba, Winnipeg, MB R3T 2N2, Canada., Williams RJ; The Graeme Clark Institute, University of Melbourne, Melbourne, VIC, Australia.; iMPACT, School of Medicine, Deakin University, Waurn Ponds, VIC 3216, Australia., Nisbet DR; Department of Biomedical Engineering, University of Melbourne, Parkville, VIC 3010, Australia.; The Graeme Clark Institute, University of Melbourne, Melbourne, VIC, Australia.; ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, ANU College of Health & Medicine, Canberra, ACT, Australia.; Research School of Chemistry, ANU College of Science, Canberra, ACT, Australia.; Melbourne Medical School, Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, Melbourne, VIC, Australia.; Founder and Scientific Advisory of Nano Status, Building 137, Sullivans Creek Rd, ANU, Acton, Canberra, ACT, Australia., Bruggeman KF; Laboratory of Advanced Biomaterials Research, School of Engineering, Australian National University, Canberra, ACT, Australia.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2024 Jun 19; Vol. 27 (8), pp. 110307. Date of Electronic Publication: 2024 Jun 19 (Print Publication: 2024).
DOI:	10.1016/j.isci.2024.110307
Abstrakt:	Neural diseases are challenging to treat and are regarded as one of the major causes of disability and morbidity in the world. Stem cells can provide a solution, by offering a mechanism to replace damaged circuitry. However, obtaining sufficient cell sources for neural regeneration remains a significant challenge. In recent years, waste-derived stem(-like) cells (WDS-lCs) extracted from both prenatal and adult clinical waste tissues/products, have gained increasing attention for application in neural tissue repair and remodeling. This often-overlooked pool of cells possesses favorable characteristics; including self-renewal, neural differentiation, secretion of neurogenic factors, cost-effectiveness, and low ethical concerns. Here, we offer a perspective regarding the biological properties, extraction protocols, and preclinical and clinical treatments where prenatal and adult WDS-lCs have been utilized for cell replacement therapy in neural applications, and the challenges involved in optimizing these approaches toward patient led therapies. Competing Interests: The authors declare no financial interest. (© 2024 The Author(s).)
Databáze:	MEDLINE
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