Anogenital Erosive Lichen Sclerosus in a Male With Multiple Autoimmune Conditions.

Autor:	Fardos MI; Dermatology, HCA Florida Largo Hospital, Largo, USA., Nikakis J; General Medicine, Peconic Bay Medical Center/Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Riverhead, USA., Anagnostis S; Dermatology, HCA Florida Largo Hospital, Largo, USA., Moon S; Dermatology, HCA Florida Largo Hospital, Largo, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jul 19; Vol. 16 (7), pp. e64908. Date of Electronic Publication: 2024 Jul 19 (Print Publication: 2024).
DOI:	10.7759/cureus.64908
Abstrakt:	Lichen sclerosus (LS) is a chronic inflammatory disorder primarily affecting the anogenital region, with a higher prevalence in females and often linked to autoimmunity. This association is not clearly elucidated in males, with LS commonly presenting in uncircumcised males. The most affected areas include the glans penis, prepuce, and coronal sulcus. In this report, we present an 11-year case of treatment-resistant LS in a male patient with an extensive history of autoimmune disorders, manifesting in the intergluteal cleft as a hypertrophic plaque, a rare location. The patient had a complex autoimmune history, including porphyria cutanea tarda, discoid lupus, and Sjogren's syndrome. Histopathological analysis confirmed a diagnosis of erosive LS. Despite numerous treatments, including intralesional corticosteroids and various topicals, the lesion persisted. This case highlights the challenges in managing LS, particularly in uncommon sites and in patients with extensive autoimmune backgrounds. Treatment goals for LS focus on symptom relief, cosmetic improvement, and disease prevention. Although topical corticosteroids are commonly used, systemic options like hydroxychloroquine may be beneficial in resistant cases, although clear guidelines are lacking. Our case underscores the importance of a multidisciplinary approach in addressing LS and its associated autoimmune conditions. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Fardos et al.)
Databáze:	MEDLINE
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