Cushing's syndrome caused by giant Ewing's sarcoma of the kidney: A case report and review of literature.

Autor:	Dong GF; Department of Urologic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China., Hou YK; Department of Urologic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China., Ma Q; Department of Urologic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China., Ma SY; Department of Urologic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China., Wang YJ; Department of Urologic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China., Rexiati M; Department of Urologic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China., Wang WG; Department of Urologic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China. wwg0903@163.com.
Jazyk:	angličtina
Zdroj:	World journal of clinical cases [World J Clin Cases] 2024 Aug 16; Vol. 12 (23), pp. 5431-5440.
DOI:	10.12998/wjcc.v12.i23.5431
Abstrakt:	Background: Primary renal Ewing's sarcoma (ES) is extremely rare, and only two cases causing Cushing's syndrome (CS) have been reported to date. We report that the case of an 18-year-old patient is diagnosed primary renal ES with typical CS characterized by purple stripes, weight gain, and hypertension. Case Summary: CS was first diagnosed by laboratory testing. A huge tumor was revealed in the kidney following an imaging examination. Moreover, brain and bone metastases were observed. After comprehensive treatment, primarily based on surgery, primary renal ES was pathologically diagnosed with a typical EWSR1-FLI1 genetic mutation through genetic testing. Furthermore, the glucocorticoid level returned to normal. By the ninth postoperative month of follow-up, the patient was recovering well. Cushing-related symptoms had improved, and a satisfactory curative effect was achieved. Conclusion: Primary renal ES, a rare adult malignant tumor, can cause CS and a poor prognosis. Competing Interests: Conflict-of-interest statement: We declare that there are no conflicts of interest between the authors. (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
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