Expression of CD44 high CD24 Low cells, SOX2, and STAT3 transcription factors on peripheral blood and tumor tissue of penile squamous cell carcinoma.

Autor: de Barros FD; Translational Research Laboratory, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil.; Hospital de Câncer de Pernambuco, Recife, Brazil.; Postgraduate Program in Translational Medicine, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil., Guimarães GC; AC Camargo Cancer Center, São Paulo, Brazil., Martins MR; Translational Research Laboratory, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil.; Hospital de Câncer de Pernambuco, Recife, Brazil.; Postgraduate Program in Translational Medicine, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil., Marinho FDS; Translational Research Laboratory, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil.; Hospital de Câncer de Pernambuco, Recife, Brazil.; AC Camargo Cancer Center, São Paulo, Brazil., Soares FA; AC Camargo Cancer Center, São Paulo, Brazil.; Rede D'Or São Luiz, São Paulo, Brazil., Torres LC; Translational Research Laboratory, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil.; Hospital de Câncer de Pernambuco, Recife, Brazil.; Postgraduate Program in Translational Medicine, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Journal of surgical oncology [J Surg Oncol] 2024 Sep; Vol. 130 (4), pp. 929-943. Date of Electronic Publication: 2024 Aug 19.
DOI: 10.1002/jso.27749
Abstrakt: Background: Penile cancer is high in some underdeveloped countries. Signal transducer and activator of transcription 3 (STAT3) and CD44, CD24, and SOX2+ are known to be markers of diagnosis and prognosis in other cancers, but without studies in penile cancer.
Methods: A cross-sectional study was conducted at the Hospital de Cancer de Pernambuco from March 2015 to December 2017. We performed SOX2, STAT3, CD24, and CD44 analyses in blood and tumor tissue by flow cytometry.
Results: High levels of CD44 high CD24 low , CD44 high CD24 low pSTAT3+ and CD44 hig h CD24 low in the blood of patients compared to the controls (p < 0.05). Low of SOX2+ T cells in blood of patients compared to controls. High CD44 high CD24 low levels in patients with perineural invasion (PNI), tumor size > 3 cm, and pT2 stage (p < 0.05). High T cell levels in the blood and tumor tissue of patients with tumor ≤3 cm (p < 0.05). Increased SOX2+ T cells in blood of patients with PNI (-) and pT1 stage (p < 0.05). CD44 high CD24l ow pSTAT3+ (r = 0.669; p = 0.024) and SOX2+T cells (r = 0.404, p = 0.029) correlation were observed between blood and tumor tissue in penile cancer patients.
Conclusion: CD44, CD24, and SOX2 molecules were markers of advanced disease associated with the worst prognosis in CaPe. However, pSTAT3 and T cells were associated with a more favorable prognosis in this study.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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