The autophagy proteome in the brain.

Autor: Ito-Silva VI; Laboratory of Neuroproteomics, Institute of Biology, University of Campinas, Campinas, Brazil., Smith BJ; Laboratory of Neuroproteomics, Institute of Biology, University of Campinas, Campinas, Brazil., Martins-de-Souza D; Laboratory of Neuroproteomics, Institute of Biology, University of Campinas, Campinas, Brazil.; D'Or Institute for Research and Education (IDOR), São Paulo, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, Brazil.; INCT in Modelling Human Complex Diseases with 3D Platforms (Model3D), São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Journal of neurochemistry [J Neurochem] 2025 Jan; Vol. 169 (1), pp. e16204. Date of Electronic Publication: 2024 Aug 18.
DOI: 10.1111/jnc.16204
Abstrakt: As one of the most important cellular housekeepers, autophagy directly affects cellular health, homeostasis, and function. Even though the mechanisms behind autophagy are well described, how molecular alterations and dysfunctions can lead to pathology in disease contexts still demands deeper investigation. Proteomics is a widely employed tool used to investigate molecular alterations associated with pathological states and has proven useful in identifying alterations in protein expression levels and post-translational modifications in autophagy. In this narrative review, we expand on the molecular mechanisms behind autophagy and its regulation, and further compile recent literature associating autophagy disturbances in context of brain disorders, utilizing discoveries from varying models and species from rodents and cellular models to human post-mortem brain samples. To outline, the canonical pathways of autophagy, the effects of post-translational modifications on regulating each step of autophagy, and the future directions of proteomics in autophagy will be discussed. We further aim to suggest how advancing proteomics can help further unveil molecular mechanisms with regard to neurological disorders.
(© 2024 International Society for Neurochemistry.)
Databáze: MEDLINE
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